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NCT ID: NCT05868564 Not yet recruiting - Clinical trials for Peripheral Arterial Disease

Atherectomy Followed With a Drug Coated Balloon in the Treatment of Long Femoropopliteal Lesions

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

The study is a prospective, multicenter, randomized pilot study to evaluate the clinical outcome of the plaque atherectomy system followed by the UltrafreeTM drug coated balloon catheter versus the drug coated balloon in patients with chronic long femoropopliteal lesions.

NCT ID: NCT05867992 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Multiomic Analysis of Serum in Acute Period of Traumatic Brain Injury

MASTER-TBI
Start date: April 1, 2024
Phase:
Study type: Observational

The goal of this experimental observation study is to figure out differently expressed biomarkers in serum in traumatic brain injury patients, compared with bone fracture patients. The main questions it aims to answer are: 1. Which proteins and metabolites are differently expressed in TBI patients' serum? 2. Which proteins or metabolites can serve as the new serum biomarkers for diagnosing TBI? Participants will be treated by routine treatments, and their serum samples will be collected in the emergency room.

NCT ID: NCT05865574 Not yet recruiting - Healthy Men Clinical Trials

A Comparative Pharmacokinetic Study to Evaluate Different Manufacturing Batches of BAT1706 Injection

Start date: June 2023
Phase: Phase 1
Study type: Interventional

This is a randomized, double-blind, single-dose, parallel two-arm study to compare the pharmacokinetics, safety, and immunogenicity of BAT1706 Injection from different manufacturing batches (by new process and old process) in healthy male subjects.

NCT ID: NCT05865366 Not yet recruiting - Clinical trials for Acute Postoperative Pain

Pain Trajectories and Predictors After Noncardiac Surgery in Elderly Patients

Start date: June 1, 2023
Phase:
Study type: Observational

This study will use group-based trajectory modeling to identify the different postoperative pain trajectory groups that exist in a mixed surgical population (non-cardiac surgery) of elderly patients during the first seven days after surgery. The aim of this study is to explore the diversity in the development of postoperative pain among elderly patients and to identify the risk factors for acute pain trajectory after surgery by investigating demographic, psychological, and clinical variables. The predictive effect of different trajectories of early postoperative acute pain on postoperative chronic pain will also be explored.

NCT ID: NCT05863871 Not yet recruiting - Clinical trials for Focus on the Lymphoma Including B/T-cell Lymphoma

Real World Study of Linperlisib for Lymphoma Treatment

MA-LYM-RWS-001
Start date: May 2023
Phase:
Study type: Observational

This is a multicenter, non-interventional and observational real-world study to evaluate the efficacy and safety of linperlisib in patients with lymphoma.

NCT ID: NCT05863273 Not yet recruiting - Psoriasis Clinical Trials

Real World Study on the Efficacy and Safety of Apremilast in Chinese Patients With Moderate to Severe Plaque Psoriasis, a Multi Center, Prospective, Observational Trial(REACT)

Start date: May 20, 2023
Phase:
Study type: Observational

This is a multicenter, one-arm, prospective, observational study,intended to assess evaluation of efficacy and safety of Apremilast in Chinese patients with moderate-to-severe plaque psoriasis。During this study, it is expected to collect data at at baseline and weeks 2, 6, 10, 16, and 20 after treatment。

NCT ID: NCT05861557 Not yet recruiting - Clinical trials for Locally Advanced Head and Neck Squamous Cell Carcinoma

Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma

Start date: May 20, 2023
Phase: Phase 2
Study type: Interventional

This is a phase II study. Twenty-three patients with locally advanced head and neck squamous cell carcinoma were planned to be enrolled to assess the efficacy and safety of neoadjuvant immunotherapy combined with radiotherapy.

NCT ID: NCT05860907 Not yet recruiting - Clinical trials for Breast Cancer Stage IV

Clinical Study of Huaier Granules in Patients With Advanced Breast Cancer Without Visceral Metastasis

Start date: October 2023
Phase: Phase 4
Study type: Interventional

This is a multicenter, open-label, randomized controlled, prospective clinical study to evaluate the efficacy and safety of Huaier Granules in patients with advanced breast cancer without visceral metastasis.

NCT ID: NCT05860569 Not yet recruiting - Clinical trials for Hypertriglyceridemia, Familial

Safety Evaluation of Gene Therapy Drug in the Treatment of Primary Hypertriglyceridemic Patients With Recurrent Pancreatitis

Start date: December 2024
Phase: Phase 1
Study type: Interventional

The study will evaluate safety and tolerance of intravenous delivery of GC304 gene therapy drug as a treatment of primary hypertriglyceridemic patients with previous onset of acute pancreatitis.

NCT ID: NCT05859750 Not yet recruiting - Pancreatic Cancer Clinical Trials

A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced Pancreatic Cancer

Start date: May 2023
Phase: Phase 2
Study type: Interventional

This study is a multicenter, open-label, phase II study to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activities of AK104,a PD-1/CTLA-4 bispecific antibody, in combination with gemcitabine and nab-paclitaxel as first-line therapy in subjects with advanced unresectable or metastatic pancreatic ductal adenocarcinoma.