There are about 28871 clinical studies being (or have been) conducted in Canada. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
This pilot study is the first step in the development of an new assay that may be further tested as a screening method for ovarian and endometrial cancers.
The study will assess the duration of protection of single doses of 2 different long acting muscarinic antagonists against methacholine induced bronchoconstriction.
The study is being conducted to evaluate two doses of TEV-48125 in adult patients with chronic migraine
Bright Light Therapy Efficacy for Depressive Symptoms Following Cardiac Surgery or Acute Coronary Syndrome: Pilot Trial (BEAM-P) is a randomized controlled trial (RCT) that seeks to assess the feasibility of conducting a full trial which would assess the efficacy of Bright Light Therapy (BLT) for improving depressive symptoms post-cardiac surgery or acute coronary syndrome.
The purpose of this study is to determine whether drinks containing Salvia hispanica L (Salba) or Flax lower postprandial blood glucose levels and improve appetite in healthy individuals.
While physical activity (PA) appears to play an important role in disease control and the promotion of long-term health and well-being of cancer survivors, the large majority of breast cancer survivors are not physically active. Addressing this problem requires exercise promotion and an additional method of supporting long term exercise adherence. In response, an innovative health coaching intervention which uses mobile technology (iMOVE) to promote long-term PA in breast cancer survivors (BrCa) was developed. Project description: 107 inactive BrCa survivors will be randomized to receive a 12-week exercise program (CONTROL) OR a 12 week exercise program plus a concurrent health coaching program (iMOVE) consisting of telephone-based coaching sessions and interactive software delivered through a smart-phone and Fit-bit (wearable fitness technology) (INTERVENTION). Information on the feasibility and acceptability of the methods and intervention and examine the impact on fitness (primary), patient-reported, anthropometric, and physical (secondary) outcomes will be collected. Impact and relevance: PA has increasingly been identified as a modifiable factor that has the potential to impact cancer outcomes and improve quality of life. iMOVE is an innovative intervention with the potential to promote and maintain physical activity for breast cancer survivors. This study will be the first step in the evaluation of iMOVE and will help to determine whether a larger randomized controlled trial is needed.
This study evaluates a novel technique for measuring the minimum pressure necessary to achieve a bloodless surgical field, known as a patient's limb occlusion pressure (LOP). Patients will have tourniquets applied to their arms and legs and LOP will be measured using the new technique and a gold standard Doppler ultrasound technique.
The main objective of the trial is to evaluate the efficacy of fasinumab compared to placebo as measured by the change from baseline in the average daily Low Back Pain Intensity (LBPI) Numerical Rating Scale (NRS). Secondary objectives of the study are to evaluate the efficacy of fasinumab compared to placebo as measured by: - Change from baseline in the Roland Morris disability questionnaire (RMDQ) total score - Change from baseline in the Patient Global Assessment (PGA) of Low Back Pain (LBP) score - Change from baseline in the average daily LBPI NRS score
The standard or usual treatment for this disease is standard chemotherapy alone. AZD2014 is a new type of drug for glioblastoma multiforme. In the laboratory it has been shown to slow the growth of glioblastoma multiforme. In some animal studies AZD2014 seemed to work better when given with a drug called temozolomide.
These days, particularly over the last decade, attention is being paid to the opinion of the patient and, in the case of pediatrics, the patient's family. Unfortunately, recent work has shown that this remains an imperfect process. Studies of inpatient families show that parents often leave hospital with only a minimal idea of side effects of drugs, who they can contact in the event that something goes wrong, and even something as simple as the date of the next medical visit. In fact, some studies have shown that adult patients don't even know the name of their doctor or nurse. While there are several papers examining the degree of unhappiness of parents in hospitals, there is very little research looking at what can be done to improve a patient's sense of satisfaction with care (and communication) while in the hospital. One suggestion has been the provision of whiteboards in the room that can allow the family to have a better idea of what is going on during the child's day. These have been suggested but never exposed to prospective, quantitative study. With the intention of improving the management of patients in the new Acute Care Centre, the department of strategic planning at Children's Hospital organized a three day IMPROVE session moderated by PHSA specialists in quality control. During this meeting, the clinical course of a child on the medical and surgical wards was mapped out. This allowed the group to examine various ideas aimed at improving the care of children passing through the hospital and the sense of parental satisfaction with the whole process. The main conclusion from the meeting (based both on available literature and the clinical experience of the group), was that communication between the medical team and parents should be improved. It was also concluded that the best way to do this would be to have a regularly updated whiteboard in each room. Prior to starting this, it was generally felt that the introduction of whiteboards should be tested in a prospective controlled manner - starting with a baseline study of patient satisfaction.