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NCT ID: NCT00412984 Completed - Atrial Fibrillation Clinical Trials

Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation

ARISTOTLE
Start date: December 31, 2006
Phase: Phase 3
Study type: Interventional

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

NCT ID: NCT00412893 Completed - Aspergillosis Clinical Trials

Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis

Start date: March 7, 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy and safety of isavuconazole versus voriconazole in the treatment of patients with invasive aspergillosis.

NCT ID: NCT00412737 Completed - Influenza Clinical Trials

A Study of Tamiflu (Oseltamivir) for the Seasonal Prophylaxis of Influenza in Immunocompromised Patients.

Start date: n/a
Phase: Phase 4
Study type: Interventional

This 2 arm study will evaluate the efficacy and safety of Tamiflu in the seasonal prophylaxis of influenza in immunocompromised patients (as represented by transplant recipients). Transplant recipients enrolled when influenza is circulating in the community will be randomized to receive Tamiflu syrup or capsules 30mg-75mg daily (depending on body weight) or placebo for 12 weeks. Influenza symptoms and safety data will be recorded throughout the study. The anticipated time on study treatment is <3 months, and the target sample size is 100-500 individuals.

NCT ID: NCT00412451 Completed - Clinical trials for Diabetic Macular Edema

A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME)

MIVI-II
Start date: December 2006
Phase: Phase 2
Study type: Interventional

A multicenter study to compare multiple doses of intravitreal microplasmin for non-surgical PVD induction for treatment of patients with DME.

NCT ID: NCT00412061 Completed - Carcinoid Tumor Clinical Trials

Everolimus and Octreotide in Patients With Advanced Carcinoid Tumor

RADIANT-2
Start date: December 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study was to evaluate whether everolimus 10 mg / day added to treatment with depot octreotide prolongs progression free survival compared to treatment with octreotide alone in patients with advanced carcinoid tumor.

NCT ID: NCT00411944 Completed - Clinical trials for Renal Transplantation

Long-Term Pharmacokinetics of Tacrolimus in Renal Recipients

Start date: August 1999
Phase: Phase 4
Study type: Observational

An evaluation of the effects of genetically determined variant metabolizing and transporting proteins involved in the disposition of the immunosuppressive drug tacrolimus in renal transplant recipients. In a five year follow-up study tacrolimus dose-corrected exposure changes significantly and the effect(s) of single nucleotide polymorphisms of the CYP3A4/CYP3A5 and MDR1 genes on the latter is assessed in this study.

NCT ID: NCT00411645 Completed - Clinical trials for Cytomegalovirus Infections

Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients

Start date: December 13, 2006
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to investigate whether or not maribavir is safe and effective for preventing CMV disease when taken by mouth for up to 12 weeks in patients who have had a stem cell transplant.

NCT ID: NCT00411541 Completed - Clinical trials for Acute Lymphoblastic Leukemia

Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia

Start date: April 1995
Phase: Phase 4
Study type: Interventional

Studies in the 1970s and 1980s suggested that the outcome of childhood acute lymphoblastic leukemia could be improved by intensification of conventional continuation chemotherapy with pulses of vincristine sulfate and steroids. We aimed to investigate the efficacy and toxic effects of vincristine-dexamethasone pulses as an addition to the continuation-therapy phase in a large cohort of children with intermediate-risk disease who were treated with the BFM treatment strategy

NCT ID: NCT00411528 Completed - Clinical trials for Metastatic Hormone Refractory Prostate Cancer

Efficacy and Safety of Patupilone in Men (≥18 Years) With Metastatic Hormone Refractory Prostate Cancer

Start date: September 2006
Phase: Phase 2
Study type: Interventional

The objective of this study is to assess the response of patupilone plus prednisone compared to docetaxel plus prednisone on prostate specific antigen (PSA) in patients with metastatic hormone refractory prostate cancer. Additionally, this study will assess the response on measureable disease and the effects on patient-reported outcomes.

NCT ID: NCT00411424 Completed - Clinical trials for Rheumatoid Arthritis

Safety, Tolerability and Efficacy Study of the New Medication ASK8007 to Treat Patients With Rheumatoid Arthritis

Start date: September 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of the new medication ASK8007, and to study whether it has a beneficial effect on joint inflammation in patients with rheumatoid arthritis.