Clinical Trials Logo

Filter by:
NCT ID: NCT05503693 Completed - Healthy Subjects Clinical Trials

A Safety, Tolerability, and Pharmacokinetics Study of AP303 in Healthy Subjects

Start date: December 6, 2022
Phase: Phase 1
Study type: Interventional

This is a single-center, randomized, double-blind, placebo-controlled, first-in-human study in which the safety, tolerability, and pharmacokinetics of orally administered AP303 will be assessed in healthy adult subjects.

NCT ID: NCT05502549 Completed - Healthy Volunteers Clinical Trials

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CB03-154 in Healthy Participants in Australia

Start date: November 29, 2022
Phase: Phase 1
Study type: Interventional

CB03-154 is an investigational drug developed by Shanghai Zhimeng Biopharma Inc. for the treatment of Epilepsy.

NCT ID: NCT05496205 Completed - Pain Clinical Trials

A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers

Start date: September 30, 2020
Phase: Phase 1
Study type: Interventional

A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.

NCT ID: NCT05491759 Completed - Clinical trials for Optimal Gastrointestinal Absorption of Omega-3

A Study to Determine Optimal Absorption of Single Dose Omega-3

Start date: August 4, 2022
Phase: Phase 4
Study type: Interventional

This is a randomised three-way cross over study comparing the optimal absorption of a single dose of fish oil using 3 different forms to one another on increasing blood concentrations of fatty acids in 24 healthy adult participants aged 19 years and over.

NCT ID: NCT05490017 Completed - Clinical trials for Paroxysmal Nocturnal Hemoglobinuria

To Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Single and Multiple Doses of KP104

Start date: December 30, 2020
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate safety, tolerability, immunogenicity, pharmacokinetics, pharmacodynamics, and efficacy of KP104 in healthy volunteers. The study will be conducted in 2 parts: Part 1, the single ascending dose (SAD) is the first in human (FIH) study of KP104 and Part 2, multiple ascending dose (MAD).

NCT ID: NCT05486728 Completed - Dry Eye Disease Clinical Trials

Phase II Study of SHJ002 Sterile Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease

Start date: February 8, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to measure efficacy and safety with SHJ002 sterile ophthalmic solution compared to vehicle in participants with Dry Eye Disease (DED). SHJ002 is an antisense oligonucleotide to neutralize a specific microRNA.

NCT ID: NCT05477186 Completed - COVID-19 Clinical Trials

Safety and Immunogenicity Study of a Booster Dose of the Investigational CV0501 mRNA COVID-19 Vaccine in Adults at Least 18 Years Old

Start date: August 12, 2022
Phase: Phase 1
Study type: Interventional

Prevention of COVID-19 caused by SARS-CoV-2.

NCT ID: NCT05476328 Completed - Hearing Loss Clinical Trials

Sound Processing. ( A Feasibility, Prospective, Repeated-measures Investigation to Investigate Innovations in Sound Processing in Adult and Paediatric Recipients Implanted With CE Approved Nucleus Cochlear Implants: an Umbrella Investigation)

Start date: January 22, 2020
Phase: N/A
Study type: Interventional

This is a feasibility, prospective with sequential enrolment, multicenter, clinical investigation in adults and paediatrics with a CE approved Nucleus cochlear implant. Subjects older than 5 years will be included. Subjects will be screened and up to 120 eligible subjects will be recruited in the clinical investigation. Subjects will attend scheduled study visits over a period up to 5 years in different sub-studies as described in the sub-study documentation. A clinical setting can consist of therapeutic elements and evaluations. Subjects will be assessed with the commercially available Nucleus sound processor or via the xPC, NIC, etc. if required. Acute testing will be done where possible. Take home use will be applied when learning effects may play a significant role and to evaluate the acceptance of the new or improved sound coding algorithm or signal processing, in as many listening environments as possible. The subject might also be asked to complete questionnaires, to perform at-home tests etc. during this take home use and/or at the clinical visits. The time for a clinical visit will be limited to a maximum of 4 hours. The time in between clinical visits will vary with typical spacing of between 0 (acute) to 4 weeks. The goals of this umbrella investigation are to measure hearing outcomes to assess performance and/or to achieve higher convenience for implant users and hearing care professionals. The outcomes of the study will guide Cochlear to select features for inclusion in future Nucleus cochlear implant systems and/or future models of care.

NCT ID: NCT05473533 Completed - Healthy Clinical Trials

Study of Single and Multiple Doses of PRS-220 Administered by Oral Inhalation in Healthy Subjects

Start date: October 31, 2022
Phase: Phase 1
Study type: Interventional

A dose escalating study of PRS-220 administered by oral inhalation in healthy subjects

NCT ID: NCT05461586 Completed - Refractive Error Clinical Trials

Clinical Investigation of Refraction Techniques

Start date: July 14, 2022
Phase:
Study type: Observational

Prospective, multi-center, non-interventional, randomized, comparative clinical study to identify an optimal refractive technique that provides maximum plus refractive endpoint for best corrected distance visual acuity (BCDVA).