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NCT ID: NCT00430729 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease. Ratio-Study. (BY217/M2-112)

Start date: January 2003
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of 500mcg roflumilast vs placebo on exacerbation rate and pulmonary function as well as quality of life in patients with chronic obstructive pulmonary disease (COPD).

NCT ID: NCT00430547 Completed - Clinical trials for Graves' Ophthalmopathy

Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies

Start date: August 2003
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether radioactive iodine, as compared to anti-thyroid medications, is a risk factor for the development or progression of thyroid-associated ophthalmopathy in patients with hyperthyroidism due to Graves' disease. The other aim of this study is to determine the incidence of the various ophthalmopathy subtypes and the utility of orbital antibodies in the diagnosis, classification and monitoring of patients with thyroid-associated ophthalmopathy.

NCT ID: NCT00430352 Completed - Clinical trials for Non-Hodgkin's Lymphoma

MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma.

Start date: September 2006
Phase: Phase 4
Study type: Interventional

This single arm study will evaluate the safety and efficacy of MabThera maintenance therapy following a MabThera-containing induction regimen in first line or relapsed patients with follicular non-Hodgkin's lymphoma. All patients will receive MabThera 375mg/m2 body surface area, as an intravenous infusion, every 8 weeks. The anticipated time on study treatment is 1-2 years, and the target sample size is 500+ individuals.

NCT ID: NCT00428948 Completed - Clinical trials for Polycystic Kidney Disease, Autosomal Dominant

Tolvaptan Phase 3 Efficacy and Safety Study in ADPKD

TEMPO3/4
Start date: January 2007
Phase: Phase 3
Study type: Interventional

This study's purpose is to evaluate the long-term safety and efficacy of tolvaptan versus placebo in patients with ADPKD.

NCT ID: NCT00428220 Completed - Clinical trials for Non-Small Cell Lung Cancer

A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.

Start date: July 2007
Phase: N/A
Study type: Interventional

This is a study using sunitinib for patients ending treatment on a previous sunitinib malate protocol to continue to receive sunitinib. The patient must have been enrolled in one of the following studies: A6181030, A6181064, A6181078, A6181087, A6181094, A6181107, A6181108, A6181110, A6181111, A6181112, A6181113, A6181120, A6181126 and A6181170. Other Pfizer sponsored sunitinib studies may be included in the future.

NCT ID: NCT00427635 Completed - GERD Clinical Trials

Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients

Start date: October 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the difference between esomeprazole and placebo in the treatment of signs and symptoms as observed by 8-hour video and cardiorespiratory monitoring in neonatal patients.

NCT ID: NCT00427141 Completed - Clinical trials for Infections, Bacterial

A Three-Part Study Of GSK580416 In Healthy Subjects

Start date: October 2006
Phase: Phase 1
Study type: Interventional

Studies for GSK580416 have been completed in rats and dogs. The main toxic effects seen in animals affected the digestive system and blood cells. Study OPS106400 will be the first administration of GSK580416 in humans. Parts A and B of this study will examine the safety, tolerability, and pharmacokinetics of increasing single doses of GSK580416 with reference to placebo. Part C of the study will assess the effect of food on the safety, tolerability, and pharmacokinetics of a single dose of GSK580416 in healthy subjects.

NCT ID: NCT00427050 Completed - Actinic Keratoses Clinical Trials

A Study to Determine the Optimal Tolerated Regime and Safety of PEP005 Topical Gel

Start date: January 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the optimal tolerated regime of PEP005 for the treatment of actinic keratoses of the face or face and scalp.

NCT ID: NCT00426803 Completed - Clinical trials for Acquired Bleeding Disorder

Recombinant Factor VIIa in Acute Intracerebral Haemorrhage

Start date: August 2002
Phase: Phase 2
Study type: Interventional

This trial is conducted in North America, Europe, Asia and Oceania. The purpose of this study is to evaluate safety and efficacy of Recombinant Factor VIIa in patients with acute intracerebral bleeding.

NCT ID: NCT00426764 Completed - Clinical trials for Peripheral T-cell Lymphoma

A Trial of Romidepsin for Progressive or Relapsed Peripheral T-cell Lymphoma

Start date: June 19, 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the activity of romidepsin in patients with progressive or relapsed peripheral T-cell lymphoma (PTCL) who have already been treated with systemic therapy.