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GERD clinical trials

View clinical trials related to GERD.

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NCT ID: NCT06241183 Recruiting - GERD Clinical Trials

Famotidine and Antacids for Treatment of Dyspepsia

Start date: November 9, 2023
Phase: Phase 4
Study type: Interventional

The aim of this study is to compare intravenous famotidine, an H2 receptor antagonist, and Maalox/ Mylanta, an oral antacid, in treatment of dyspepsia in the emergency department. The goal of this study is to reduce patients' pain based on the verbal numerical pain scale. The anticipated outcome is for pain levels in both groups to decrease. It is expected that antacids will improve symptoms more quickly and to a greater degree within an hour of taking medication based on the results of similar studies.

NCT ID: NCT06159972 Recruiting - GERD Clinical Trials

Can EndoFLIP Improve Quality of Life Before and After Fundoplication?

Start date: January 5, 2023
Phase: N/A
Study type: Interventional

Patients with reflux disease (heart burn), or a hiatal hernia, who do not get better with medication, may have surgery to help with their symptoms. Unfortunately, there is no agreed upon way to perform the surgery. The investigators are using a new surgical instrument called the EndoFLIP which allows surgeons to take measurements during the operation. The investigators will compare the measurements obtained during surgery with a quality of life score that we will calculate from a questionnaire.

NCT ID: NCT06157424 Completed - GERD Clinical Trials

Efficacy and Safety of Combined Thread Embedding Acupuncture With Auricular Acupuncture for GERD

Start date: December 6, 2023
Phase: N/A
Study type: Interventional

Gastroesophageal reflux disease (GERD) is increasingly prevalent today. Proton-pump inhibitors (PPIs) are the primary treatment, yet their effectiveness remains limited. Various acupuncture methods have shown promise in treating GERD. Among these, thread embedding acupuncture (TEA) and auricular acupuncture (AA) offer the advantage of prolonged treatment per intervention, significantly reducing healthcare visits for procedures, particularly beneficial for conditions requiring extended therapy. This has led to the widespread application of TEA and AA in GERD treatment. However, evidence supporting their effectiveness remains inconclusive. In this study, we aim to assess the efficacy and safety of combining TEA with AA for treating GERD. According to traditional medicine, treatment should be pattern-based. Thus, we will focus on patients exhibiting the Liver Qi Invading Stomach pattern, as reports indicate its prevalence among GERD patients.

NCT ID: NCT06141577 Completed - GERD Clinical Trials

A Study to Compare Pharmacokinetics, Pharmacodynamics and Safety of UI059 and UIC202201 in Healthy Subjects

Start date: October 8, 2023
Phase: Phase 1
Study type: Interventional

A randomized, open-label, multiple-dose crossover phase 1 clinical trial to compare and evaluate the safety, pharmacokinetics and pharmacodynamics characteristics after oral administration of UI059 and UIC202201 in healthy adult volunteers

NCT ID: NCT06126055 Not yet recruiting - GERD Clinical Trials

Endoscopic Band Ligation for Treating Reflux Disease

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

GERD is a chronic disease the require different treatment modalities; non have proven long term efficacy with concerns about their safety. The use of band ligation in endoscopy appears safe, repeatable with short learning curve. Placing multiple bands at the Z-line can create a fibrous ring in the distal esophagus acting as a barrier against reflux of gastric content.

NCT ID: NCT06084572 Recruiting - GERD Clinical Trials

Prospective Evaluation of pH-impedance Tracings According to the Wingate Consensus, and Influence on GERD Classification According to the Lyon Consensus

WinPro
Start date: September 29, 2023
Phase:
Study type: Observational

Commonly, in clinical practice an automated analysis of pH-MII tracings is obtained.

NCT ID: NCT05974722 Recruiting - GERD Clinical Trials

Mesh Vs Pledgets for Repair of Paraesophageal Hernia

Start date: September 11, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: - Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. - Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

NCT ID: NCT05899491 Recruiting - GERD Clinical Trials

Role of ARMA in Selective Subset of Refractory GERD Patients.

Start date: March 30, 2023
Phase: N/A
Study type: Interventional

To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).

NCT ID: NCT05874726 Recruiting - Obesity Clinical Trials

Biological Sample Repository for Gastrointestinal Disorders

Start date: July 19, 2023
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients presenting with short- and long-term surgical complications. The aim is to enhance the overall understanding of the mechanisms leading to obesity, weight loss, failure to lose weight, and weight regain following treatment. Additional goals are to determine the efficacy of endoscopic and surgical procedures, to identify potential therapeutic targets and disease biomarkers that predict response to therapy.

NCT ID: NCT05870163 Recruiting - Clinical trials for Gastroesophageal Reflux Disease (GERD)

Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment

Start date: February 20, 2023
Phase:
Study type: Observational [Patient Registry]

This post-market registry aims to assess safety and performance of RefluxStop™ in the treatment of Gastroesophageal Reflux Disease (GERD) in standard of care procedures.