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NCT ID: NCT04901078 Completed - Opioid-use Disorder Clinical Trials

A Phase 1 Study Investigating the Safety, Tolerability and Pharmacokinetics of KNX100 in Healthy Volunteers

KTX101
Start date: April 7, 2022
Phase: Phase 1
Study type: Interventional

The primary objectives of this study are to evaluate the safety and tolerability of KNX100 administered orally as a single and multiple ascending doses in healthy volunteers.

NCT ID: NCT04899336 Recruiting - Clinical trials for Invasive Extraintestinal Pathogenic Escherichia Coli Disease (IED) Prevention

A Study of Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years

Start date: June 30, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate the efficacy of 9-valent extraintestinal pathogenic Escherichia coli vaccine (ExPEC9V) compared to placebo in the prevention of the first invasive extraintestinal pathogenic Escherichia coli disease (IED) event caused by ExPEC9V O-serotypes.

NCT ID: NCT04899310 Recruiting - Clinical trials for Methylmalonic Acidemia

A Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of mRNA-3705 in Participants With Isolated Methylmalonic Acidemia

Start date: August 6, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This is a study of mRNA-3705 in participants with isolated elevated methylmalonic acid (MMA) due to methylmalonyl-coenzyme A (CoA) mutase (MUT) deficiency. The main goal of the study is to assess safety, pharmacokinetics, and pharmacodynamics of mRNA-3705.

NCT ID: NCT04898673 Completed - Clinical trials for Adult Cochlear Implant Recipients

CP1110 Sound Processor Feasibility

Start date: October 25, 2021
Phase: N/A
Study type: Interventional

The clinical study aims to investigate the speech performance with the CP1110 Sound Processor, compared with the CP1000 Sound Processor, and inclusion of a noise reduction feature in the Automatic Scene Classifier..

NCT ID: NCT04898426 Recruiting - Colon Polyp Clinical Trials

Effect of Enhanced Interactive Text Messages and Phone Instruction on the Quality of Bowel Preparation for Colonoscopy.

Start date: August 13, 2021
Phase: N/A
Study type: Interventional

Efficacy Evaluation of Enhanced Bowel Preparation Instructions in Elective Colonoscopy.

NCT ID: NCT04898348 Withdrawn - Ulcerative Colitis Clinical Trials

A Study to Investigate Efficacy and Safety of KBL697 in Patients With Mild to Moderate Active Ulcerative Colitis

Start date: January 14, 2022
Phase: Phase 2
Study type: Interventional

The study is designed to investigate efficacy and safety of KBL697 in patients with mild to moderate active ulcerative colitis. KBL697 has been developed as a potential new treatment for ulcerative colitis.

NCT ID: NCT04897880 Terminated - Rhabdoid Tumor Clinical Trials

A Study of Panobinostat in Pediatric Patients With Solid Tumors Including MRT/ATRT

NORTH
Start date: January 9, 2019
Phase: Phase 2
Study type: Interventional

This trial is evaluating the anti-tumor activity and side effects of panobinostat in treating patients with osteosarcoma, malignant rhabdoid tumor/atypical teratoid rhabdoid tumor (MRT/ATRT), and neuroblastoma.

NCT ID: NCT04897412 Completed - Subcutaneous Fat Clinical Trials

A Study to Evaluate the Efficacy, Safety, and Tolerability of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 2)

Start date: February 14, 2022
Phase: Phase 2
Study type: Interventional

The Stage 2 of this phase 2 study will be a randomized, single-blind, placebo-controlled, parallel, and multiple-dose study to assess the efficacy, safety, and subject satisfaction of CBL-514.

NCT ID: NCT04896515 Completed - Critically Ill Clinical Trials

INTENT-Muscle (A Sub-study of INTENT)

Start date: June 21, 2021
Phase:
Study type: Observational

The currently recruiting randomised controlled trial "Intensive Nutrition Therapy Compared to Usual Care in Critically Ill Adults" (INTENT, NCT03292237) is the first multi-centre trial to compare an intensive, individualised nutrition intervention to standard care for the duration of hospital admission in critically ill patients. INTENT-Muscle, is an observational longitudinal study nested within INTENT. The aim of INTENT-Muscle is to compare longitudinal changes in muscle health (assessed by bioimpedance and muscle ultrasound) in critically ill patients randomised to each arm of INTENT.

NCT ID: NCT04896021 Active, not recruiting - Clinical trials for Cardiovascular Diseases

Improved Cardiovascular Disease hEALth Service Delivery in Australia: Cluster Randomised Controlled Trial (IDEAL Study)

IDEAL
Start date: May 26, 2021
Phase: N/A
Study type: Interventional

The IDEAL study is a randomized controlled trial among people referred to pathology services to have blood cholesterol measured. Study participants will have cardiovascular risk factors (e.g. age, sex, blood pressure, diabetes, smoking status) measured within an assessment station at pathology services. A report on cardiovascular risk, in addition to blood cholesterol results, will be sent to the referring doctor along with recommended treatment strategies among those participants randomized to intervention. For control participants, the usual care process will be provided in which only blood cholesterol results will be sent to the referring doctor. The new intervention is expected to lead to better identification and treatment of people at high risk for cardiovascular disease events.