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NCT ID: NCT03653026 Completed - Clinical trials for Ulcerative Colitis (UC)

A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis

U-Accomplish
Start date: December 6, 2018
Phase: Phase 3
Study type: Interventional

The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission (per Adapted Mayo score) in participants with moderately to severely active ulcerative colitis (UC).

NCT ID: NCT03650218 Completed - Clinical trials for Correction of Nasolabial Folds

Safety and Effectiveness of THIODERM STRONG in the Correction of Nasolabial Folds

Start date: July 10, 2018
Phase: N/A
Study type: Interventional

This is a prospective, open label, dose-escalating, multicenter clinical investigation to evaluate the safety and effectiveness of THIODERM STRONG in the correction of nasolabial folds. The performance is assessed using the 5-point Nasolabial Folds Severity Rating Scale (NLF-SRS) at Week 12 compared to baseline.

NCT ID: NCT03648541 Completed - Colitis, Ulcerative Clinical Trials

BI 655130 Long-term Treatment in Patients With moderate-to Severe Ulcerative Colitis

Start date: October 29, 2018
Phase: Phase 2
Study type: Interventional

To evaluate the long-term safety of BI 655130 (SPESOLIMAB) in patients with moderate to severely active ulcerative colitis, who have completed treatment in previous trials To evaluate the long-term efficacy of BI 655130 (SPESOLIMAB) in patients with moderate to severely active ulcerative colitis, who have completed treatment in previous trials

NCT ID: NCT03646695 Completed - Macular Holes Clinical Trials

ILM Flap Transposition Versus ILM Peeling for Macular Holes: a Pilot Study

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Patients with macular hole <400µm will be randomized for ILM flap Transposition and ILM Peeling for surgical repair of macular holes

NCT ID: NCT03646682 Completed - Epiretinal Membrane Clinical Trials

Pharmakokinetik of Caffeine in Epiretinal Membranes After Oral Intake: a Pilot Study

Start date: August 13, 2018
Phase: N/A
Study type: Interventional

Caffeine concentrations in the vitreous Body and exzised epiretinal membranes are measured by gas-chromatography/mass spectrometry.

NCT ID: NCT03644875 Completed - Cataract Surgery Clinical Trials

Study of Etacoat in Patients With Cataract Surgery Via the Anterior Chamber

Start date: June 28, 2018
Phase:
Study type: Observational

This is a prospective, single center, non-comparative, 90-day follow-up, post-market clinical investigation of etacoat in patients undergoing cataract surgery. The performance is evaluated by the preservation of endothelial cells measured by specular microscopy at the follow-up visit in comparison to baseline values.

NCT ID: NCT03644862 Completed - Cataract Surgery Clinical Trials

Study of Etafill in Patients With Cataract Surgery Via the Anterior Chamber

Start date: January 29, 2019
Phase:
Study type: Observational

This prospective, single center, non-comparative, 90-day follow-up, post-market clinical investigation of etafill in patients undergoing cataract surgery. The performance is measured by the preservation of endothelial cells measured by specular microscopy at the follow-up visit in comparison to baseline values.

NCT ID: NCT03644680 Completed - Allergic Rhinitis Clinical Trials

Changes in Adaptive Immune Responses and Effector Cell Responses Upon Nasal Allergen Exposure - a Pilot Study

Start date: September 24, 2018
Phase: N/A
Study type: Interventional

IgE-associated allergy is a hypersensitivity disease affecting more than 25% of the population in industrialised countries. The recognition of allergen by immunoglobulin E (IgE) plays a central role in the cause of allergic diseases. Both seasonal and nasal provocation studies have demonstrated the rise in specific IgE after allergen exposure. Additionally changes in other clinical and immunological parameters (e.g. nasal blockage, mast cell and basophil sensitivity, various cytokines or T cell profiles) in response to allergen exposure have been described. However the time sensitive interplay of these various factors such as the relationship between rise in IgE levels and change in basophils sensitivity or cytokine profiles is not yet fully understood. Clarifying how these various factors interact and contribute to immunological responses to allergen, is crucial for the development of new therapeutic approaches. The investigators aim to address these questions through a study following 36 Birch allergic patients after provocation with allergen or placebo over a peroid of 6 weeks to 1 year.

NCT ID: NCT03642821 Completed - Clinical trials for Intracranial Aneurysm

Intracranial Aneurysms Treatment With the OPTIMA Coil System

INSTANT
Start date: March 1, 2019
Phase:
Study type: Observational [Patient Registry]

International, non-randomized, European , multicenter, observational study to collect data for the treatment of intracranial aneurysms with OPTIMA coils system to further document its safety and efficacy

NCT ID: NCT03635983 Completed - Melanoma Clinical Trials

A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma

Start date: September 21, 2018
Phase: Phase 3
Study type: Interventional

The purpose of the study is to test the effectiveness (how well the drug works), safety, and tolerability of the investigational drug called NKTR-214, when combined with nivolumab versus nivolumab given alone in participants with previously untreated melanoma skin cancer that is either unable to be surgically removed or has spread