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NCT ID: NCT01449175 Terminated - Emphysema Clinical Trials

A Registry Study of the AeriSeal® System or Lung Volume Reduction in Patients With Advanced Emphysema

Start date: January 2011
Phase: N/A
Study type: Observational

The purpose of this study is to provide post market clinical follow-up (PMCF) to obtain long term safety and efficacy information about the AeriSeal System treatment in patients with advanced emphysema.

NCT ID: NCT01445197 Terminated - Hemophilia A Clinical Trials

Study of Biostate for Treatment of Children With Hemophilia A Complicated by Antibody Development

Start date: December 2012
Phase: Phase 3
Study type: Interventional

This is a clinical study to investigate how well Biostate works in treatment of male patients below the age of 12 years who have a clotting factor deficiency that is aggravated by the development of antibodies. The antibodies are directed against the clotting factor that is given for replacement therapy and usually make therapy unsuccessful. The treatment used in this study is called immune tolerance therapy.

NCT ID: NCT01424267 Terminated - Clinical trials for Abdominal Aortic Aneurysm

Zenith® LP Abdominal Aortic Aneurysm (AAA) Post-Market Registry

Start date: July 2010
Phase: N/A
Study type: Observational

A registry to collect additional prospective intra-operative and follow-up information on physician use of the CE-marked Zenith® Low Profile Abdominal Aortic Aneurysm (AAA) Endovascular Graft under routine clinical care.

NCT ID: NCT01403064 Terminated - Oral Mucositis Clinical Trials

Safety and Efficacy of ALD518 for Reducing Oral Mucositis in Head and Neck Cancer Subjects

Start date: July 2011
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of ALD518 in modifying the course of oral mucositis in subjects with head and neck cancer receiving concomitant chemotherapy and radiotherapy

NCT ID: NCT01397149 Terminated - Clinical trials for Chronic Lymphocytic Leukemia

Eltrombopag in Thrombocytopenic Chronic Lymphocytic Leukemia (CLL) Patients (CLL2S Study of GCLLSG)

Start date: October 2011
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this study is to find the appropriate dose of eltrombopag in thrombocytopenic CLL patients, that shortens the duration of the thrombocytopenia and achieves platelet count of ≥ 100/nl prior to the start of chemotherapy containing alkylating agents and/or Purine Analogues.

NCT ID: NCT01382888 Terminated - Haemodialysis Clinical Trials

Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis

Start date: July 2011
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to evaluate the effect of topically applied heparin in comparison to placebo on suitability of newly constructed primary arteriovenous fistulas in patients planned for haemodialysis at 7th week (± 1 week) after first study drug administration.

NCT ID: NCT01378390 Terminated - Crohn Disease Clinical Trials

Safety and Efficacy of Adipose-Derived Stem Cells to Treat Complex Perianal Fistulas Patients With Crohn's Disease

FATT
Start date: December 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine safety and efficacy of eASCs (expanded adult stem cells) for treatment of complex perianal fistulas in patients with Crohn's disease.

NCT ID: NCT01376700 Terminated - Hemophilia A Clinical Trials

Early Prophylaxis Immunologic Challenge (EPIC) Study

EPIC
Start date: August 26, 2011
Phase: Phase 3
Study type: Interventional

The purpose of the study was to assess if a once-weekly prophylactic regimen of 25 IU/kg ADVATE started at or before 1 year of age and before the onset of a severe bleeding phenotype (ie, joint bleeding), together with the minimization of immunological danger signals, can reduce the incidence rate of inhibitor formation in PUPs with severe and moderately severe hemophilia A.

NCT ID: NCT01375374 Terminated - Epilepsy, Partial Clinical Trials

Hormonal and Lipid Levels in Male Subjects After a Switch From Carbamazepine to Lacosamide

VICTOR
Start date: July 2011
Phase: Phase 3
Study type: Interventional

The purpose of the trial is to investigate whether changes in lipids and hormonal parameters can be observed in blood when Carbamazepine treatment is replaced with Lacosamide treatment, while Levetiracetam treatment remains unchanged.

NCT ID: NCT01375166 Terminated - Clinical trials for Diabetic Retinopathy

Coupling of Neural Activity and Retinal Blood Flow in Diabetes

Start date: March 6, 2013
Phase:
Study type: Observational

The prevalence of diabetes is increasing and the management of the disease is nowadays considered a major challenge. Affected patients have increased mortality and morbidity as well as a significant drop in the quality of life. The complications of diabetes can be classified as microvascular (e.g. nephropathy, neuropathy or retinopathy) or macrovascular (e.g. cardiovascular or cerebrovascular). Several large-scale epidemiologic studies indicating that wider retinal venous caliber is strongly associated with the fasting glucose level as well as with diabetes. Another retinal vascular abnormality that is associated with diabetes is an abnormal retinal vascular response to flicker stimulation. Retinal vessel dilatation in response to stimulation with diffuse flicker light occurs due to a phenomenon called neurovascular coupling. This means that increased activity of neurons is associated with an increased retinal metabolism. This leads to a release of endogenous vasodilator substances and increased blood flow. However, previous studies were limited by the fact that retinal vessel diameters and blood flow were not measured simultaneously. The present study aims to investigate whether the response of retinal vessel diameters and blood flow velocities to flicker stimulation is altered in patients with diabetes. Both parameters will be measured in real time using Fourier Domain Doppler OCT.