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NCT ID: NCT00785785 Completed - Clinical trials for Gastrointestinal Stromal Tumor (GIST)

A Study of Nilotinib Versus Imatinib in GIST Patients

ENESTg1
Start date: March 2009
Phase: Phase 3
Study type: Interventional

This study will evaluate efficacy and safety of nilotinib versus imatinib in adult patients with unresectable or metastatic gastrointestinal stromal tumors (GIST).

NCT ID: NCT00783744 Completed - Clinical trials for Diabetes Mellitus, Type 2

Insulin Glargine Combination Therapies in Type II Diabetics

LAPTOP
Start date: December 2001
Phase: Phase 3
Study type: Interventional

To compare efficacy of combination therapy of insulin glargine plus glimepiride and metformin versus 2 injections insulin monotherapy with premixed insulin NPH 30/70 bid in terms of change of HbA1c (baseline to endpoint) to show non-inferiority of insulin glargine plus glimepiride and metformin.

NCT ID: NCT00783510 Completed - Clinical trials for Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis (JIA) Registry

STRIVE
Start date: July 11, 2008
Phase:
Study type: Observational

This is a global registry, to evaluate the long-term safety of Humira® in patients with moderate to severe polyarticular Juvenile Idiopathic Arthritis (JIA), that are treated as recommended in the Humira® product label. Patients treated with MTX will be considered a reference group. Patients will be followed in both the Humira® and Methotrexate (MTX) arms for 10 years from the enrollment date into one of the treatment arms.

NCT ID: NCT00782171 Completed - Partial Edentulism Clinical Trials

Evaluation of Immediate Versus Delayed Loading of Dental Implants With a Modified Surface

Start date: July 2004
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the performance of a new dental implant with a modified surface in different loading protocols.

NCT ID: NCT00782067 Completed - Leukemia Clinical Trials

Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia

Start date: October 13, 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study was to determine the efficacy and safety of twice daily (bid) oral midostaurin in patients with Aggressive Systemic Mastocytosis (ASM) or Mast Cell Leukemia (MCL) with or without an Associated Hematological clonal Non-Mast cell lineage Disease (AHNMD).

NCT ID: NCT00781352 Completed - Colorectal Cancer Clinical Trials

Nitrous Oxide and Risk of Cancer Recurrence After Colorectal Surgery: A Randomized, Blinded Study

Start date: November 1998
Phase: Phase 3
Study type: Interventional

This study was developed to test the hypothesis that the risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.

NCT ID: NCT00778388 Completed - Healthy Clinical Trials

Study Assessing Safety and Immunogenicity of IC43 Vaccination Against Pseudomonas Aeruginosa in Healthy Volunteers

Start date: September 2008
Phase: Phase 1
Study type: Interventional

The objective is to confirm the optimal dose of IC43 in regard to immunogenicity, safety and tolerability.

NCT ID: NCT00778102 Completed - Colorectal Cancer Clinical Trials

A Study of Avastin (Bevacizumab) in Combination With mFOLFOX-6 or FOLFOXIRI in Patients With Metastatic Colorectal Cancer.

Start date: October 2008
Phase: Phase 2
Study type: Interventional

This 2 arm study will compare the resection rate of liver metastases and safety of surgery in patients with metastatic colorectal cancer and primarily unresectable liver metastases receiving treatment with Avastin in combination with 5-FU, leucovorin and oxaliplatin with irinotecan (FOLFOXIRI) or without irinotecan (mFOLFOX-6) as first line treatment. Patients will be randomized to receive Avastin (5mg/kg iv every 2 weeks) in combination with each of these two standard neoadjuvant chemotherapy regimens. The anticipated time on study treatment is until surgery, disease progression, unacceptable toxicity or patient refusal, and the target sample size is <100 individuals.

NCT ID: NCT00777803 Completed - Clinical trials for Glabellar Frown Lines

NT 201 (Xeomin®/Bocouture®) in Comparison With Clostridium Botulinum Toxin Type A in the Treatment of Glabellar Frown Lines

Head2Head
Start date: November 2008
Phase: Phase 3
Study type: Interventional

NT 201, also known as IncobotulinumtoxinA (Xeomin®/Bocouture®), is a Botulinum toxin type A preparation free of complexing proteins (150 kiloDalton). Injected into the muscle, NT201 causes a reversible local relaxation of the injected muscle. Botulinum toxin type A is used for aesthetic treatment of mimic wrinkles and in the therapy of neurologic diseases. This study will investigate the safety and efficacy (non-inferiority) of NT 201 in comparison with OnabotulinumtoxinA (Vistabel®) in the treatment of glabellar frown lines.

NCT ID: NCT00777127 Completed - Actinic Keratosis Clinical Trials

Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses

LEIDA
Start date: December 2008
Phase: Phase 4
Study type: Interventional

This clinical trial serves the purpose to compare the long-term effects of a treatment of actinic keratosis - your skin disorder - using Aldara® 5% cream or Solaraze® 3% gel on the face or the scalp. In particular, it should be found out whether the healing effect of these two medications on the skin lesions (i.e. the damaged skin parts) can be maintained for a prolonged period.