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NCT ID: NCT00843778 Completed - Clinical trials for Rheumatoid Arthritis

Follow-up of Rheumatoid Arthritis (RA) Moderate to Low Disease Activity Study

CERTAIN 2
Start date: January 2009
Phase: Phase 3
Study type: Interventional

To continue to assess the clinical safety and efficacy of Certolizumab Pegol as add-on therapy with stable-dose Disease Modifying Anti-Rheumatic Drugs (DMARDs)

NCT ID: NCT00842387 Completed - Heartburn Clinical Trials

Evaluation Study of a Management Strategy for Gastroesophageal Reflux Disease (GERD)

Start date: January 2009
Phase: N/A
Study type: Observational

The aim of this project is to compare the GERD clinical outcomes in patients where a structured pathway using the GerdQ questionnaire is implemented compared with the clinical outcomes of those treated without this implementation. This is a European project with 5 participating countries (Austria, Italy, Norway, Spain and Sweden). Due to different characteristics regarding the actual management of this disease in the 5 countries, each country had the flexibility to introduce design differences and changes in the study protocol.

NCT ID: NCT00842322 Completed - Clinical trials for Kidney Transplantation

Fluid Intake in Kidney Failure

Start date: n/a
Phase: N/A
Study type: Interventional

Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation. In contrast,high fluid intake could be dangerous if urine excretion is reduced. In this study the researchers investigate whether increasing fluid intake from 2 to 4 litres per day has any influence on long-term renal outcome.

NCT ID: NCT00840801 Completed - Clinical trials for Encephalitis, Tick-Borne

Immunogenicity, Safety and Interchangeability of Two Tbe Vaccines Administered According to a Conventional Schedule in Children

Start date: February 6, 2009
Phase: Phase 3
Study type: Interventional

The objective of this study is to assess the immunogenicity, safety and interchangeability of two different TBE vaccines in children aged 1-11 years, the first and second vaccination with either FSME-IMMUN 0.25ml Junior or Encepur 0.25ml Children and the third vaccination with FSME-IMMUN 0.25 ml Junior only, administered according to the conventional schedule (0, 28 and 360 days).

NCT ID: NCT00840671 Completed - Stroke Clinical Trials

Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke

CERE-LYSE-1
Start date: October 2005
Phase: Phase 3
Study type: Interventional

It should be shown that Cerebrolysin in combination with Alteplase, the medication that should recover the blood flow through the brain, is an effective and save medication to treat ischeamic stroke.

NCT ID: NCT00839826 Completed - Thromboembolism Clinical Trials

ODiXahip - a Phase IIa Dose Escalating Proof of Principle Trial

ODiXaHip
Start date: December 2002
Phase: Phase 2
Study type: Interventional

Patients undergoing surgery, especially hip and knee surgery, are at high risk for VTE (up to 60 % without prophylaxis). The administration of drugs for thromboprophylaxis, such as heparins, significantly lowers that risk, but heparins have to be applied below the skin (subcutaneously). Additionally, there is a chance of developing a heparin-induced thrombocytopenia (decrease in platelets). Therefore, there is still a need for new agents which are safer and more efficient and which are easier to apply.The purpose of this study is to compare the safety and efficacy of BAY 59-7939 with the safety and efficacy of the licensed drug Enoxaparin. Enoxaparin, a so-called low molecular heparin, is approved and widely used in the area of thromboprophylaxis and will be given once daily subcutaneously.Another important purpose of the study is to find the optimal dose of BAY 59-7939 for thromboprophylaxis after hip replacement surgery. Therefore, there are several dose steps planned.

NCT ID: NCT00839163 Completed - Clinical trials for Deep Vein Thrombosis

Oral Direct Factor Xa Inhibitor BAY59-7939 in Patients With Acute Symptomatic Proximal Deep Vein Thrombosis(ODIXa-DVT)

Start date: March 2004
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of BAY59-7939 with the safety and efficacy of the licensed drug enoxaparin and a licensed oral vitamin K-antagonist and to find the optimal dose of BAY59-7939 for the anticipated phase III trials and for the future clinical use.

NCT ID: NCT00837811 Completed - Clinical trials for Rheumatoid Arthritis

An Open Label Extension Study in Participants With Rheumatoid Arthritis

Start date: February 2009
Phase: Phase 2
Study type: Interventional

To evaluate the safety and tolerability of LY2127399 administered as subcutaneous injections for 48 weeks in participants with Rheumatoid Arthritis

NCT ID: NCT00836914 Completed - Allergic Rhinitis Clinical Trials

Study to Investigate Effects of CAL-101 in Subjects With Allergic Rhinitis Exposed to Allergen in an Environmental Chamber

Start date: February 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and effect of CAL-101 in subjects with allergic rhinitis.

NCT ID: NCT00835770 Completed - Clinical trials for Relapsing-Remitting Multiple Sclerosis

BG00012 Monotherapy Safety and Efficacy Extension Study in Multiple Sclerosis (MS)

ENDORSE
Start date: February 3, 2009
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the long-term safety profile of BG00012 (dimethyl fumarate). Secondary objectives of this study are to evaluate the long-term efficacy of BG00012 using clinical endpoints and disability progression, to evaluate further the long-term effects of BG00012 on multiple sclerosis (MS) brain lesions on magnetic resonance imaging (MRI) scans in participants who had MRI scans as part of Studies 109MS301 (NCT00420212) and 109MS302 (NCT00451451) and to evaluate the long-term effects of BG00012 on health economics assessments and the visual function test.