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NCT ID: NCT02781935 Completed - Colorectal Cancer Clinical Trials

Diffusion-Weighted MRI for Liver Metastasis

DREAM
Start date: November 2016
Phase:
Study type: Observational

The DREAM study will assess the diagnostic accuracy of diffusion-weighted MRI in combination with other imaging modalities (multiparametric MRI and CT Scan) in determining the true status of disappearing liver metastasis (DLM) detected after conversion systemic therapy for unresectable or borderline resectable colorectal liver metastasis (CRLM).

NCT ID: NCT02775903 Completed - Clinical trials for Myelodysplastic Syndromes

An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)

Start date: June 3, 2016
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to evaluate the efficacy of subcutaneous azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in adults with previously untreated, higher risk MDS who are not eligible for HSCT or in adults ≥ 65 years old with previously untreated AML who are not eligible for HSCT, with intermediate or poor cytogenetic risk.

NCT ID: NCT02774616 Completed - Heart Failure Clinical Trials

BIO|MASTER.Ilivia Family / Plexa

Start date: June 2016
Phase: N/A
Study type: Interventional

Post-Market Clinical Follow-up of the new Ilivia ICD Family and the new Plexa right ventricular lead to fulfill requirements by the notified body and to support regulatory approval outside of the CE region

NCT ID: NCT02774005 Completed - Clinical trials for Leber's Hereditary Optic Neuropathy (LHON)

Study to Assess the Efficacy and Safety of Raxone in LHON Patients

LEROS
Start date: May 2016
Phase: Phase 4
Study type: Interventional

LEROS is an open-label interventional Phase IV study, designed to further assess the efficacy and safety of Raxone® in the long-term treatment of LHON patients.

NCT ID: NCT02771379 Completed - Clinical trials for Leber's Hereditary Optic Neuropathy (LHON)

Post Authorisation Safety Study With Raxone in LHON Patients

PAROS
Start date: September 2016
Phase:
Study type: Observational

This study is a multicentre, prospective, non-interventional post-authorisation safety study (PASS) of the clinical outcomes for patients with LHON treated with Raxone®. No medication will be provided as part of this study. Raxone® will be obtained through commercial channels.

NCT ID: NCT02771184 Completed - Pulmonary Fibrosis Clinical Trials

Computerized Lung Sound Analysis

CLSA
Start date: April 2016
Phase: N/A
Study type: Interventional

This clinical trial is conducted within the research project 'Computerized Lung Sound Analysis'. The research goal is the development of a system enabling the automatic classification of lung sounds, which will result in a decision support system for physicians. The objective of this trial is to create a small lung sound corpus, enabling the development of a prototype of the described system. Therefore, investigators record lung sounds with several lung sound transducers distributed on the posterior chest of human test subjects.

NCT ID: NCT02770131 Completed - Clinical trials for Hypercholesterolaemia

Chart Review of Repatha® in Subjects With Hyperlipidaemia

HEYMANS
Start date: May 4, 2016
Phase:
Study type: Observational

Review of clinical characteristics of patients who are prescribed Repatha® and how their treatment is managed.

NCT ID: NCT02769728 Completed - Obesity Clinical Trials

EndoBarrier in Obese Subjects With Type 2 Diabetes Mellitus

Start date: February 2016
Phase: N/A
Study type: Interventional

The aim of the study is to explore short and longer-term effects of the Endobarrier™ implantation on insulin resistance and beta-cell function assessed by repeated Botnia clamps. In addition changes in gut peptides and gut permeability after implantation of a removable duodeno-jejunal bypass device to induce diabetes remission in obese subjects with sub-optimally controlled type 2 diabetes mellitus will be determined. Further changes in body weight and body composition, the change in global cardiovascular risk from baseline to 12 months, estimated using the UKPDS risk engine will be recorded.

NCT ID: NCT02769273 Completed - Clinical trials for Peripheral Arterial Disease

Stellarex Vascular E-Registry

SAVER
Start date: June 2016
Phase:
Study type: Observational [Patient Registry]

Prospective, international, multi-center, single arm, observational study to continue to assess the treatment by the Stellarex™ OTW Drug-coated Angioplasty Balloon in superficial femoral and/or popliteal arteries according to the Instructions for Use in a broad, real-world, claudicant or ischemic rest pain patients population per the institution's standard practice.

NCT ID: NCT02765035 Completed - Clinical trials for Lower Limb Amputation Above Knee (Injury)

C-Leg 3 and C-Leg 4 Study in Transfemoral Amputees

Start date: April 2016
Phase: N/A
Study type: Interventional

The aim of this post-market study is to confirm that the microprocessor controlled prosthetic knee components (C-Leg 3 and C-Leg 4) in comparison to mechanical knee joints can bring additional benefit to the users primarily on level walking and secondarily in safety, stair and hill mobility, activities of daily living, satisfaction and preference.