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NCT ID: NCT03259269 Recruiting - Clinical trials for Tuberculosis, Multidrug-Resistant

Expand New Drugs for TB [endTB]

Start date: February 9, 2016
Phase: N/A
Study type: Observational

This observational study will examine the safety and efficacy of bedaquiline and delamanid used (individually, not together) in routine, multidrug regimens for treatment of MDR-TB. The information gathered in this study will inform doctors how best to use these TB drugs in the future.

NCT ID: NCT03072992 Recruiting - Clinical trials for Metastatic Breast Cancer

"Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer

Start date: March 20, 2017
Phase: Phase 2
Study type: Interventional

The aim of this study is to assess benefits of treatment with intravenous Curcumin® (CUC-01) vs placebo, in combination with paclitaxel chemotherapy, and to estimate the risk of adverse events in patients with locally advanced and metastatic breast cancer. This is a randomized, double-blind, placebo-controlled, two arms parallel group phase 2 clinical trial: Group A, 75 patients, treatment with Curcumin (CUC-01, yellow solution), 300mg i.v. plus i.v. Paclitaxel (colorless solution) 80 mg /m2 BS i.e., once weekly for 12 weeks. Group B, 75 patients, treatment with Paclitaxel (colorless solution) 80 mg /m2 BS, i.v. plus placebo i.v. solution (250 ml, yellow solution for masking/blinding), once weekly for 12 weeks. Primary objective of the study: To assess: - Efficacy of combined therapy with Curcumin ®, (CUC-01) and Paclitaxel vs Paclitaxel in patients with advanced and metastatic breast cancer in terms of Objective Response Rate (ORR) assessed with the Modified Response Evaluation Criteria In Solid Tumours (RECIST). Secondary objectives of the study: To assess: - The safety of Curcumin+Paclitaxel combination compared to Paclitaxel+placebo treatment by assessment of adverse effects. - Quality of life (QOL) in patient treated with Curcumin+Paclitaxel combination compared to Paclitaxel+Placebo - Response duration in terms of Progression free survival (PFS), Time to Disease Progression (TTP) and Time to treatment failure (TTTF)

NCT ID: NCT03014193 Not yet recruiting - Medical Abortion Clinical Trials

Simplifying First Trimester Medical Abortion Follow-up

Start date: January 2017
Phase: N/A
Study type: Observational

This study evaluates the usability of the multilevel pregnancy test among women undergoing medical abortion.

NCT ID: NCT02983019 Completed - Influenza Clinical Trials

Treatment of Influenza in Routine Clinical Practice

FLU-EE
Start date: December 2013
Phase: N/A
Study type: Observational

This study evaluates the statistics of influenza and acute respiratory viral infections (ARVI) management in outpatient sites in Russia, Armenia, Moldova and Georgia (epidemiology: disease severity and bacterial exacerbations; patients demography; treatment duration and timelines; safety; quality of treatment) in routine clinical practice with focus on drug therapy and usage of interferons' inducers.

NCT ID: NCT02873806 Active, not recruiting - Open-angle Glaucoma Clinical Trials

Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents

Start date: March 2013
Phase: Phase 4
Study type: Interventional

The study objective was to evaluate the intraocular pressure (IOP) lowering effect of two iStent devices in eyes of subjects with primary open-angle glaucoma, washed out of two anti-glaucoma medications (one a Prostaglandin) prior to stent implantation.

NCT ID: NCT02868190 Active, not recruiting - Open Angle Glaucoma Clinical Trials

Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication

Start date: March 2013
Phase: Phase 4
Study type: Interventional

This study objective is to evaluate the intraocular pressure (IOP) lowering effect of two trabecular micro-bypass stents (iStent inject) in eyes of subjects with primary open-angle glaucoma on one topical hypotensive medication

NCT ID: NCT02772484 Completed - Stroke Clinical Trials

An Evaluation of Non-invasive ICP Monitoring in Patients Undergoing Routine Care

Start date: April 2016
Phase: N/A
Study type: Interventional

The HS-1000 device, an investigational intracranial monitoring device, has the potential to safely and quickly diagnose and assess stroke (and potentially other neurologic conditions) with minimal discomfort to patients. HS-1000 has the capability to establish cerebral hemodynamic measurements in suspected stroke within minutes, assist with appropriate management of stroke, and also provide an objective diagnostic tool for clinicians to monitor recovery.

NCT ID: NCT02708446 Recruiting - Clinical trials for Legally Induced Abortion Without Mention of Complication

A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion

Start date: May 2014
Phase: Phase 4
Study type: Interventional

The primary goal of this study is to directly compare repeat doses of sublingual and buccal routes of 400 mcg misoprostol following mifepristone for second trimester abortion in order to determine if sublingual route confers an advantage with respect to efficacy and median time to complete abortion.

NCT ID: NCT02632825 Recruiting - Clinical trials for Respiratory Insufficiency

Effects of Nasal High Flow Therapy on Ventilation and Gas Exchange in Healthy Newborns

Start date: May 2015
Phase: N/A
Study type: Interventional

Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. It has been shown in adults that NHF produce different effects on ventilation during wakefulness and sleep. There is no physiological data on effects of NHF in neonates. The physiological effects may be impacted by sleep/awake status.

NCT ID: NCT02632799 Completed - Clinical trials for Respiratory Insufficiency

Airway Pressure During Nasal High Flow and CPAP in Neonates

Start date: January 2015
Phase: N/A
Study type: Interventional

Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.