Coronary Disease Clinical Trial
Official title:
The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study)－A Prospective Multicenter Cohort Study-
The purpose of this study is to determine the clinically meaningful definition and prevalence of aspirin resistance based on data linking aspirin-dependent laboratory tests to recurrent vascular events in cardiovascular patients taking aspirin.
Primary Outcomes: The primary endpoint is the composite outcomes of cerebral infarction,
transient ischemic attack, myocardial infarction, unstable angina, percutaneous coronary
angiography, thromboembolism, and death caused by cardiovascular disease.
Secondary Outcomes: Platelet aggregation induced by collagen and arachidonic acid, serum
thromboxane B2, urine 11-dehydrothromboxane B2, platelet thrombus formation under flow
conditions (sub-study only at the National Cardiovascular Center)
The primary objective of this study is to determine the markers for aspirin resistance. To
achieve this objective, platelet aggregation, serum thromboxane B2, and urine
11-dehydrothromboxane B2 are measured in patients receiving usual therapeutic doses of
aspirin, who experienced acute coronary syndrome, cerebral infarction, or transient ischemic
attack occurred in a period between the past 1 month and the past 2 years. This is a
multi-center, prospective study.
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Observational Model: Cohort, Time Perspective: Prospective
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