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A Comparative Study of Indobufen and Aspirin in Patients With Coronary Atherosclerosis

Coronary Atherosclerosis Clinical Trial

Official title:
A Comparative Study on Antiplatelet Efficacy of Indobufen and Aspirin in Patients With Coronary Atherosclerosis

Clinical Trial Summary

In addition, studies have found that indobufen can inhibit coagulation function in rats. Compared with aspirin, the duration of antiplatelet efficacy of indobufen was shorter, and the platelet function recovered completely 24 hours after drug withdrawal. However, there are few studies on the antiplatelet efficacy of indobufen. The investigators' previous study found that the inhibitory effect of indobufen 100 mg Bid on COX system in atherosclerosis or healthy volunteers was equivalent to that of aspirin 100 mg QD, but the inhibitory effect on platelet COX-1 channel was significantly weaker than that of aspirin 100 mg QD. In view of this, this study intends to investigate the antiplatelet effect of indobufen 200 mg Bid in patients with coronary atherosclerosis by comparing it with conventional-dose aspirin 100 mg QD.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05105750
Study type Interventional
Source The First Affiliated Hospital with Nanjing Medical University
Contact Li Chunjian, Ph.D
Phone 86-25-83718836
Email lijay@njmu.edu.cn
Status Recruiting
Phase Phase 4
Start date October 15, 2021
Completion date March 20, 2022
View Details
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