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NCT05369702 Clinical Trial

Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes

Coronary Artery Disease Clinical Trial

Official title:
Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes- A Case Control Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05369702
Other study ID # 47/19/IEC/JMMC&RI
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2019
Est. completion date April 30, 2021

Study information
Verified date May 2022
Source Jubilee Mission Medical College and Research Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Primary objective- To study the association of Lewis antigen and A, B, O blood group phenotypes with coronary artery disease patients attending the tertiary care hospital in Kerala. The secondary objective-To find the association of Lewis antigen and A, B, O blood group phenotypes with smoking, alcohol use, diabetes, hypertension and dyslipidemia. A case-control study to compare the prevalence of Lewis(a-b-) blood group among confirmed cardiac cases with the prevalence of the same among the general population and thereby find out if individuals with Lewis(a-b-) are more at risk of developing coronary artery disease. This may provide an economical and simple method for identifying subjects at increased risk for coronary artery disease and subsequently lead to more focused preventive measures and eventually to a specific treatment.

Recruitment information / eligibility
Status Completed
Enrollment 210
Est. completion date April 30, 2021
Est. primary completion date April 30, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 30 Years to 55 Years
Eligibility Inclusion Criteria: - Patients in the age group of 30-55 years at the time of data collection diagnosed with coronary artery disease based on positive changes in coronary angiogram (more than 70% coronary stenosis) Exclusion Criteria: - Patients with other systemic illnesses like malignancy, autoimmune diseases. - Patients who were not willing to participate in the study.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
India Jubilee Mission Medical College & Research Institute Thrissur Kerala

Sponsors (1)
Lead Sponsor Collaborator
Jubilee Mission Medical College and Research Institute

Country where clinical trial is conducted

India, 

Outcome
Type Measure Description Time frame Safety issue
Primary Prevalence of Lewis and ABO blood group phenotypes in cases and controls. Prevalence Lewis and ABO phenotype in cases will be compared to prevalence of the same in controls. Lewis and ABO phenotype of the study participants was determined immediately after sample collection
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