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Impaired HDL and Coronary Artery Disease in Anabolic Androgenic Steroid Users

Coronary Artery Disease Clinical Trial

Official title:
Diminished Macrophage Cholesterol Efflux Mediated by HDL and Coronary Artery Disease in Young Male Anabolic Androgenic Steroid Users

Clinical Trial Summary

Anabolic androgenic steroids (AASs) have been associated with coronary artery disease (CAD). The illicit use of these substances also leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. The investigators tested the functionality of HDL by cholesterol efflux and antioxidant capacity and its association with CAD in young men.

Clinical Trial Description

Twenty strength-trained AAS users (AASU) age 29±5 yr, 20 age-matched strength-trained AAS nonusers (AASNU), and 10 sedentary controls (SC) were enrolled.

HDL concentration and functionality by measuring the 14C-cholesterol efflux mediated by HDL and the ability of HDL in inhibiting LDL oxidation were evaluated.

Coronary artery was evaluated with coronary computed tomography angiography. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03450837
Study type Observational
Source University of Sao Paulo General Hospital
Contact
Status Completed
Phase N/A
Start date April 1, 2015
Completion date April 1, 2017
View Details
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