The Association Between Central Aortic Blood Pressure Indices and Severity of Coronary Artery Disease

Coronary Artery Disease Clinical Trial

— CAPCAD  

Official title:

The Association Between Central Aortic Blood Pressure Indices and Severity of Coronary Artery Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02471768
• Other study ID #: Ref No IRC/2013/Protocol/162
• Status: Completed
• Phase: N/A
• First received: June 8, 2015
• Last updated: June 15, 2015
• Start date: April 2014
• Est. completion date: June 2015

Study information

• Verified date: June 2015
• Source: Government Medical College, Kozhikode
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Abstract

Objectives:

Primary: To study the association between central aortic blood pressure indices and coronary artery disease in patients undergoing elective angiography. Secondary: (a) To study whether any association exists between central aortic pressure indices and the incidence of major adverse cardiovascular events (MACE) in the same patients during a 6 month follow up period. (b) To study whether any association exists between the central aortic pressures and peripheral pressures.

Methods: The investigators conducted a prospective observational study in consecutive patients undergoing coronary angiography. Central and peripheral pressures were invasively recorded and coronary artery disease (CAD) classified into obstructive and non-obstructive group. CAD severity was graded using the Gensini score and subjects were divided into tertiles. Patients were followed up and the role of central aortic pressure indices in the prediction of cardiovascular events were analysed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 623
• Est. completion date: June 2015
• Est. primary completion date: March 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• Patients undergoing elective angiography for diagnosis of CAD.

• Age > 18 years

Exclusion Criteria:

• Patients with acute myocardial infarction, unstable angina or thromboembolism in the preceding 3 months.

• More than mild valvular heart disease.

• Renal impairment with serum creatinine > 1.5 mg%.

• Unable to obtain a full study of the coronary arteries.

• Peripheral vascular occlusive disease.

• Post coronary artery bypass grafting( CABG)

• Heart rate < 50/min and > 120/min and other arrhythmias.

• Contraindications for coronary angiography.

• Unable to provide written informed consent

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Intervention

Procedure:
• CORONARY ANGIOGRAM AND CENTRAL AORTIC WAVEFORM ANALYSIS
coronary angiogram

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Government Medical College, Kozhikode

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	acute coronary syndrome(ACS)		6 MONTHS
Primary	stroke		6 months
Primary	revascularisation		6 months
Primary	death		6 months