Coronary Artery Disease Clinical Trial
Background:
Only around 20% of all patients seen in hospital with suspected Acute Coronary Syndrome will
have Acute Myocardial Infarction. However, several studies indicate that patients where ACS
had been excluded by conventional methods sustain a higher cardiac morbidity and mortality
than the background population. Not all of these patients can be identified by traditional
risk factors such as cholesterol, hypertension, and diabetes or with conventional methods
such as ECG, troponin and clinical symptoms. Non-Contrast Cardiac-CT measures the amount of
calcification in the coronary arteries and might be a useful addition in predicting future
cardiac events in this patient group. The aim of this study is through a double-blinded
study to determine whether non-contrast CT scan with calcium score can be used to identify
patients at increased risk of death and cardiac event within the following 12 months after
an acute admission where troponin measurements were normal.
Methods:
The study will investigate patients with suspected Acute Coronary syndrome who have been
examined and subsequently sent home from an emergency- or cardiology department without ACS
or another obvious explanation. 750 patients, age 30-70 years who are included in the study:
"Identification of risk factors in non-cardiac chest pain patients" will be offered a
non-contrast CT scan with calcium score within 14 days after the hospital contact. The
participants will be included in a 12 months follow up, where the result of the calcium
score is not revealed neither for the patient nor the investigator. After 12 months the
results of the scan is compared with the rate of cardiac events. This project is a
multicenter study and recruits patients from 6 emergency - and cardiology departments in the
region of Southern Denmark.
The study commences at September 2014 and results of this project are expected to contribute
to the risk stratification of Non-cardiac chest pain patients.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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