Aerobic Exercise on Ventilatory Efficiency in CAD Patients

Coronary Artery Disease Clinical Trial

Official title:

Effect of Aerobic Exercise Training on Ventilatory Efficiency in Patients With Coronary Artery Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02106533
• Other study ID #: 53/2010
• Status: Completed
• Phase: Phase 2
• First received: March 27, 2014
• Last updated: April 7, 2014
• Start date: August 2011
• Est. completion date: May 2013

Study information

• Verified date: April 2014
• Source: Hospital TotalCor
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Description:

Measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. In addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak VO2.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 123
• Est. completion date: May 2013
• Est. primary completion date: June 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 48 Years to 77 Years

Eligibility

Inclusion Criteria:

• was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria:

• unstable angina pectoris,

• complex ventricular arrhythmias,

• pulmonary congestion and

• orthopaedic or neurological limitations to exercise

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Complication, Cardio-respiratory
• Coronary Artery Disease
• Coronary Disease
• Exercise Addiction
• Myocardial Ischemia

Intervention

Other:
• Aerobic exercise training
The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Hospital TotalCor

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Ventilatory efficiency in patients with coronary artery disease	Measurements of ventilatory efficiency during cardiopulmonary exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs.	up to 3 months of the interventions	Yes