Vascular Function on the First Day After Cardiac Surgery

Coronary Artery Disease Clinical Trial

Official title:

Vascular Function on the First Day After Cardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02001090
• Other study ID #: REK nr 2013/1758
• Status: Completed
• Phase: N/A
• First received: November 27, 2013
• Last updated: September 18, 2017
• Start date: December 2013
• Est. completion date: April 29, 2014

Study information

• Verified date: September 2017
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique. Increased flow is achieved trough obstructing blood flow with a cuff around the forearm for five minutes. FMD is measured before surgery and on the first morning after the operation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: April 29, 2014
• Est. primary completion date: April 29, 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• admitted for coronary artery bypass surgery

Exclusion Criteria:

• Ongoing treatment with nitrates or RAAS inhibiting drugs

• unstable coronary syndrome

• unstable circulation/shock

• renal failure

• hepatic failure

• autoimmune or inflammatory disease

• untreated hypertension.

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Locations

Country	Name	City	State
Norway	St. Olavs Hospital	Trondheim	Sør Trøndelag

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	St. Olavs Hospital

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Dedichen HH, Hisdal J, Skogvoll E, Aadahl P, Kirkeby-Garstad I. Reduced reactive hyperemia may explain impaired flow-mediated dilation after on-pump cardiac surgery. Physiol Rep. 2017 May;5(10). pii: e13274. doi: 10.14814/phy2.13274. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	flow mediated dilation of the brachial artery	Transitory change in FMD as a consequence of cardiac surgery with use of extra corporal circulation.	one day
Secondary	Reactive hyperemia	Transitory change in reactive hyperemia after five minutes of occlusion of forearm blood flow as a consequence of cardiac surgery with the use of extra corporal circulation.	one day