Coronary Artery Disease Clinical Trial
Official title:
A Psycho-biochemical Perspective on Non-significant Coronary Artery Disease: a Prospective Cohort Study of Classic and Novel Risk Markers.
Psychosocial factors have been found to be associated with an increased risk for coronary
artery disease incidence, progression and worse clinical outcomes.
Patients with non-significant coronary artery disease (confirmed vascular irregularities,
but <60% coronary occlusion) often present with complaints such as chest pain, which warrant
screening by coronary angiography (CAG) or computed tomography (CT scan). The prognosis of
this group of patients with mild stenosis remains to be investigated in more detail, and we
propose that psychosocial factors play a role in the clinical prognosis and patient reported
outcomes in this group.
A special focus lies within examining personality characteristics, of which Type D
personality is a primary predictor variable for prognosis. Type D personality is
characterised by high negative affect and high social inhibition. In addition to
psychosocial factors (personality, mood state, social support, SES),
biomarkers(inflammation, clotting, DNA) as well as standard clinical risk factors (metabolic
syndrome, activity level, smoking, medication use, disease severity) will be investigated.
The goal of the proposed study is to investigate a preexisting psycho-biochemical risk
profile for major adverse cardiovascular events (MACE) and patient perceived symptoms in a
group with angiographically or CT-scan confirmed, non-significant coronary artery disease.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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