Coronary Artery Disease Clinical Trial
Official title:
Effect of Statin on the Post-interventional Coronary Microcirculation Dysfunction
The purpose of this study is to evaluate the effect of statin on the coronary microcirculation dysfunction measured after percutaneous coronary intervention.
Development of peri-procedural myocardial infarction following percutaneous coronary
intervention (PCI) is not uncommon and affects long-term prognosis. Clinical studies have
shown that pre-treatment with atorvastatin reduced peri-procedural myocardial infarction in
patients with stable angina. The mechanism of peri-procedural myocardial infarction is
presumed to be microvascular embolization. However the direct causal relationship between
statin pretreatment and prevention of microvascular dysfunction has not been investigated
yet.
In this study, we will recruit symptomatic angina patients who have clinical indication of
coronary angiography. At the time of enrollment, patients will be randomly assigned to
pre-treatment group (atorvastatin 80 mg/d for 4 days) or control group. Percutaneous
coronary intervention (PCI) will be perfomed based on the result of diagnostic coronary
angiography by decision of attending physician. When PCI is performed, fractional flow
reserve (FFR) and index of microvascular resistance (IMR) will be measured before and after
the procedure. Periprocedural myocardial infarction will be defined by post-PCI cardiac
biomarker. All patients will be followed for adverse cardiac events for 1 year.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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