Adenosine-induced Stress Dynamic Myocardial Perfusion Imaging With Dual-source CT

Coronary Artery Disease Clinical Trial

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01680081
• Other study ID #: 1-2011-0064
• Status: Terminated
• Phase: Phase 4
• Start date: January 30, 2012
• Est. completion date: July 11, 2016

Study information

• Verified date: January 2019
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study was designed as a prospective multicenter trial to determine the accuracy of combined CT coronary angiography and perfusion imaging, specifically quantitative dynamic perfusion imaging in patients with suspicious coronary artery disease compared conventional coronary angiography and quantitative dynamic perfusion MRI as standard reference.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 51
• Est. completion date: July 11, 2016
• Est. primary completion date: July 11, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

1. Men and women patients, with age ranging 40-80.

2. Suspected coronary artery disease who are supposed to undergo invasive coronary angiography with appropriate clinical indications

3. Patients who are willing to sign the informed consent form

Exclusion Criteria:

1. Contraindication of CT Known allergy to iodinated contrast media or history of contrast-induced nephropathy Decreased renal function: elevated serum creatinine(>1.5mg/dl) Contraindication to beta-blockers Severe arrhythmia: arterial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)

2. Contraindication of MRI Claustrophobia Metallic hazards Pacemaker implant eGFR<30 ml/min

3. Unstable or uncooperative patients

4. Limited life expectancy due to cancer or end-stage renal or liver disease

5. Evidence of severe symptomatic heart failure (NYHA Class III or IV)

6. Previous myocardial infarction, coronary artery intervention, coronary artery bypass surgery, or other cardiac surgery

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Intervention

Other:
• Adenosine stress dynamic CT perfusion

Locations

Country	Name	City	State
Korea, Republic of	Severance hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnostic accuracy of stress induced CT perfusion	Diagnostic accuracy of combined stress and rest dynamic CT perfusion and coronary angiography with dual x-ray sources in detection of hemodynamically significant stenosis of coronary artery compared with conventional coronary angiography and perfusion MRI in patients with suspicious coronary artery disease.	10-30 days