Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients

Coronary Artery Disease Clinical Trial

Official title:

Effect of Continuous and Interval Exercise Training on PETCO2 Response During Graded Exercise Test in Patients With Coronary Artery Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01515033
• Other study ID #: 117/11
• Status: Completed
• Phase: Phase 2
• First received: January 18, 2012
• Last updated: January 20, 2012
• Start date: September 2010
• Est. completion date: August 2011

Study information

• Verified date: January 2012
• Source: Hospital TotalCor
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (PETCO2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among PETCO2 at ventilatory anaerobic threshold (VAT) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.

Description:

End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions. Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation. In this regard, it has been shown that patients with cardiac disease have an abnormally low PETCO2 during exercise, especially those with an impaired response of cardiac output during exercise

Recruitment information / eligibility

• Status: Completed
• Enrollment: 37
• Est. completion date: August 2011
• Est. primary completion date: June 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years to 79 Years

Eligibility

Inclusion Criteria:

• was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria:

• unstable angina pectoris,

• complex ventricular arrhythmias,

• pulmonary congestion and

• orthopaedic or neurological limitations to exercise

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Complication, Cardio-respiratory
• Coronary Artery Disease
• Coronary Disease
• Exercise Addiction
• Myocardial Ischemia

Intervention

Other:
• aerobic exercise training
The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold. The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Hospital TotalCor

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	PetCO2 response during graded exercise test	End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation	before and after 3 months of the interventions	Yes