Coronary Artery Disease Clinical Trial
Official title:
The Contribution of Lp-PLA2 Level to the Presence of Coronary Plaques in Patients With Non Alcoholic Fatty Liver Disease
The most common cause of death in patients with NAFLD(Nonalcoholic Fatty Liver Disease) is CAD(Coronary Artery Disease). NAFLD patients have 65% more mortality than general population. The aim of the investigators study is to diagnose early coronary artery disease in NAFLD patient by measuring of PLA2. The investigators expect that PLA2 will higher in patients with patients with combination of CAD, unstable plaque and NAFLD.
Background: The most common cause of death in patients with NAFLD(Nonalcoholic Fatty Liver
Disease) is CAD(Coronary Artery Disease). NAFLD patients have 65% more mortality than
general population. The aim of our study is to diagnose early coronary artery disease in
NAFLD patient by measuring of PLA2.
Methods: 60 patients with chest pain and low to intermediate risk for coronary events will
undergo Cardiac CT and blood test measurement of enzyme PLA2, markers of inflammation: CRP,
MDA(Malondialdehide), Paraoxonase, FFA(Free Fatty Acids), TG(Triglycerids) will performed.
CAD is defined as a stenosis of more than 50% in at least one major coronary artery,
unstable plaque defined as low attenuated plaque <30HU and fatty liver defined as difference
in liver and spleen attenuation value -10HU by using CT.
Expected results : we expect that PLA2 will higher in patients with patients with
combination of CAD, unstable plaque and NAFLD.
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Time Perspective: Prospective
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