Coronary Artery Disease Clinical Trial
Official title:
Methods to Augment the Efficacy of Aspirin and Clopidogrel in Healthy Subjects (ASA Only) and Patients With Stable Coronary Artery Disease (Taking Clopidogrel Only) or (Taking Clopidogrel & ASA) With an Elevated Platelet Turnover (Reticulated Platelets).
The investigators will test the hypothesis that aspirin or clopidogrel taken twice daily will augment their antiplatelet efficacy in patients with an elevated platelet turnover (as measured by the proportion of reticulated (young) platelets) compared with once daily dosing.
1. To study whether in healthy subjects with an increased platelet turnover, a twice daily
dosing of aspirin 81 mg will be more effective in inhibiting platelets compared with
once a day aspirin 81 mg.
2. To study whether in patients with stable coronary artery disease (CAD) with an increased
platelet turnover, a twice daily dosing of aspirin 81 mg will be more effective in
inhibiting platelets compared with once a day aspirin 81 mg.
3. To study whether in healthy subjects with an increased platelet turnover, a twice daily
dosing of aspirin 81 mg and clopidogrel 75 mg will be more effective in inhibiting
platelets compared with once daily of both aspirin and clopidogrel.
4. To study whether in patients with stable coronary artery disease (CAD), increased
platelet turnover and aspirin resistance, an oral fatty acid (docosahexaenoic acid (DHA)
and eicosapentanoic acid (EPA), 4 gm/day) supplementation will increase the efficacy of
aspirin by modifying platelet function compared to once a day aspirin 81 mg.
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