Coronary Artery Disease Clinical Trial
Official title:
Detection of Vulnerable Plaque With Coronary Vessel Wall MRI: Contrast Enhanced MRI With Gadofosveset MS-325.
MRI has the ability to visualize the arterial vessel wall. Wall thickening and
atherosclerotic plaque components can be visualized in the carotid arteries and the aorta.
Previous studies also demonstrated the ability of MRI to visualize the coronary vessel wall.
The ultimate goal of coronary vessel wall imaging is to detect vulnerable atherosclerotic
plaque thereby. This might prevent complications, e.g., chest pain (angina) or myocardial
infarction.
The goal of this study was to validate MRI of the coronary vessel wall by comparing it to
intravascular ultrasound (IVUS), to detect atherosclerotic plaque in the coronary vessel
wall and to look at the uptake of the albumin-binding contrast agent gadofosveset in
atherosclerotic plaques. The main hypothesis is that due to the albumin binding
characteristics, uptake of the contrast agent will take place in the more vulnerable plaques
compared to less vulnerable plaques. MRI will be compared to X-ray coronary angiography and
intravascular ultrasound, two techniques currently considered as the standard of reference
for imaging of the coronary arteries and vessel wall.
n/a
Primary Purpose: Diagnostic
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