Coronary Artery Disease Clinical Trial
Official title:
Prompt Human Coronary Collateral Vasomotor Function Induced by Dynamic Physical Exercise
The purpose of this study in humans with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate if dynamic physical exercise leads to an instantaneous improvement of coronary collateral function.
The existence of coronary collateral vessels and their benefit against cardiac events have
been recognized for many years, but their functional capacity in response to physical
exercise has partially remained elusive. Via endothelial shear stress, the fundamental
stimulus for collateral development, exercise theoretically leads to collateral vasodilation
and recruitment by an increase in heart rate and blood pressure during exercise. Moreover,
the phenomenon of "walking through angina" indicates that collateral function and physical
activity are related and their interaction is of clinical relevance.
The purpose of the present study in humans with stable coronary artery disease was to assess
the instantaneous response of coronary collateral function to dynamic physical exercise.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic
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