Coronary Artery Disease Clinical Trial
Official title:
Characterization of Factors Influencing the Occurrence of Cognitive Decline in Patients With Coronary Artery Disease and Undergoing Cardiac Surgery and Coronary Angioplasty
The real impact of cardiac surgery and coronary angioplasty remains to be clarified and,
where appropriate, the influencing factors in a way beneficial or deleterious remain to be
identified.
The identification of such factors could make even faster screening, prevention and
therefore open therapeutic prospects for those patients.
The objective of the study is to constitute a prospective cohort to assess the occurrence of
cognitive decline after cardiac surgery (200 patients) and coronary angioplasty (200
patients) using the scale Dementia rating scale (DRS) of Mattis. In addition, the
investigators will identify factors that influence positively or negatively, the occurrence
of such a cognitive decline. The study based on a systematic monitoring of clinical,
biological, imaging and pharmacological factors and, to correlate the respective influence
of these factors on the incidence of cognitive decline.
Cardiovascular invasive interventions (surgery and angioplasty) save thousands of lives
every year, but questions remain about the neurological complications and in particular
cognitive deficit. Indeed, cardiac surgery has been associated with cognitive decline in 50
to 70% of patients in the first postoperative week and in 20 to 40% of patients 6 months to
one year after surgery.
The study will be based on a prospective monitoring during 1 year of a cohort of 400
patients who will receive either a cardiac surgery or coronary angioplasty. At inclusion,
will be collected medical history, risk factors, treatment history, clinical and etiological
data (imaging, cardiac and vascular balance).
The results of routine tests performed complementary to hospitalization will be recorded
(echo-doppler vessels of the neck, cardiac ultrasound trans-thoracic and/or transesophageal
a holter cardiac).
In recruiting, we will apply a method of matching based on age (on 5 years) between 2 groups
in order to compare 2 homogeneous groups.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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