Coronary Artery Disease Clinical Trial
Official title:
Coronary Atherosclerosis in Women Athletes: Asymptomatic Twin Cities Marathon Women Studied by MSCT Angiography
The aim of this study is to determine the effects of extreme fitness in women. The incidence of coronary artery disease observed via multislice computed tomography (MSCT) angiogram will be compared with age and risk-matched controls from both sedentary and fitness activity groups who have never been significant runners. Life style, training volume and risk factors will be assessed.
Single-center, non-randomized, prospective, observational study. The study population will
be up to 100 female athletes who are competitive long distance runners, and have been so for
a minimum of 10 years. Multi-slice computed tomography (MSCT) will be used to characterize
the amount, severity and type of atherosclerotic lesions. MSCTA will be performed per usual
practice using a minimum X-ray dose protocol.
The study will determine whether moderate to high intensity, long term athletic training and
competition is associated with enhanced coronary artery disease in women. Each participant
will complete a life-style, training volume and risk factor questionnaire. These
participants will be compared to an age, gender and risk factor matched cohort.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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