Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease

Coronary Artery Disease Clinical Trial

— ADVANCE-PCI  

Official title:

ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Patients Undergoing Percutaneous Coronary Intervention

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00905294
• Other study ID #: INFACTs 2009-001
• Status: Terminated
• Phase: N/A
• First received: May 19, 2009
• Last updated: June 17, 2013
• Start date: August 2009
• Est. completion date: August 2010

Study information

• Verified date: June 2013
• Source: University College Cork
• Contact: n/a
• Is FDA regulated: No
• Health authority: Ireland: Medical Ethics Research Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease. The investigators hypothesize that the relationship between these factors could potentially be useful in identifying patients at higher risk for heart attacks.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 11
• Est. completion date: August 2010
• Est. primary completion date: August 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Admission to hospital with suspected index event of Non-ST-Elevation Myocardial Infarction (NSTEMI), Unstable Angina (UA) or Stable Angina (SA)

• Planned percutaneous coronary intervention during admission

Exclusion Criteria:

• Recent history (< 6 months) of an acute coronary syndrome (other than current admission) or stroke

• Recent history (< 6 months) of major surgery, trauma or thromboembolic event

• Percutaneous coronary or peripheral intervention or any stent placement performed within the past 6 months

• Current evidence of infection

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Intervention

Other:
• Blood draws
Observational: blood draws only

Locations

Country	Name	City	State
Ireland	Cork University Hospital	Cork
Ireland	Beaumont Hospital	Dublin

Sponsors (2)

Lead Sponsor	Collaborator
University College Cork	Royal College of Surgeons, Ireland

Country where clinical trial is conducted

Ireland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels	Assess the relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels in subjects with coronary artery disease prior to and after undergoing PCI in this exploratory study	change from baseline to after percutaneous coronary intervention	No