Effect of Folic Acid Treatment in Coronary Artery Disease

Status Recruiting

Clinical Trial Summary

We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function

Clinical Trial Description

Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00300352
Study type	Interventional
Source	University of Oxford
Contact	Cheerag C Shirodaria, MB BS MRCP
Phone	+(44)1865-221866
Email	cheerag.shirodaria@cardiov.ox.ac.uk
Status	Recruiting
Phase	Phase 2
Start date	May 2004

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