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NCT00218985 Clinical Trial

Exercise-training Before Coronary Artery Bypass Graft (CABG)

Coronary Artery Disease Clinical Trial

Official title:
Exercise-training Before Coronary Artery Bypass Graft (CABG)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00218985
Other study ID # TRIM 158-04
Secondary ID
Status Completed
Phase N/A
First received September 20, 2005
Last updated February 16, 2018
Start date January 2005
Est. completion date December 2016

Study information
Verified date February 2018
Source Norwegian University of Science and Technology
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date December 2016
Est. primary completion date December 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Scheduled for CABG both with and without heart failure

Exclusion Criteria:

- Unstable angina

- Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)

- Participation in another study

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Exercise training
Intensity controlled exercise training before the scheduled bypass surgery

Locations
Country Name City State
Norway Norwegian University of Science and Technology Trondheim

Sponsors (1)
Lead Sponsor Collaborator
Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A. Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Th — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Cardiovascular function and quality of life Before and up to 1 year after intervention
Secondary Structure and function of cardiomyocytes After the intervention period
Secondary Cardiomyocyte structure and function after the intervention period
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