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NCT03196089 Clinical Trial

Effect of Short-term Oxygen During CPET in COPD

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise (CPET) Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03196089
Other study ID # KEK-ZH-NR. 2012-0251_2
Secondary ID
Status Completed
Phase Phase 2
First received
Last updated
Start date June 2, 2017
Est. completion date December 31, 2018

Study information
Verified date August 2019
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date December 31, 2018
Est. primary completion date December 31, 2018
Accepts healthy volunteers No
Gender All
Age group 20 Years to 80 Years
Eligibility Inclusion Criteria:

- diagnosis of chronic obstructive pulmonary disease

- on optimized medical therapy and in stable condition for at least 4 week

- desaturate in the 6 minute walking test by at least 4% to values <92%

Exclusion Criteria:

- unstable conditions

- pregnant women

- patients with relevant concomitant lung disease and severe daytime hypoxemia

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Oxygen application
Supplemental oxygen via mask

Locations
Country Name City State
Switzerland University Hospital Zurich, Division of Pneumology Zürich

Sponsors (1)
Lead Sponsor Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Watt 1 day
Primary Exercise time 1 day
Secondary Peak Oxygen uptake 1 day
Secondary Respiratory Exchange ratio 1 day
Secondary Ventilatory equivalent of carbon dioxide (VE/VCO2) slope 1 day
Secondary End-tidal pressures of carbon dioxide (PET CO2) 1 day
Secondary Changes in arterial blood parameters 1 day
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