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Clinical Trial Summary

A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk in obesity. Specifically, in a valid circadian protocol, the investigators aim to study resting cardiovascular risk markers and the reactivity of circadian rhythms in these risk markers to standardized stressors in obesity. Furthermore, using an ingenious approach, the investigators propose to explore impairment in pre/post synaptic function in the cardiac left ventricle.


Clinical Trial Description

Overall, these studies will help us answer whether CV rhythms predispose obese individuals to increased CV disease risk - particularly around the vulnerable morning period. The results will serve as a foundation for clinical trials of appropriately timed dosing of medications targeting aspects of the CV system in obesity that increase effectiveness while decreasing side-effects. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03388788
Study type Interventional
Source Oregon Health and Science University
Contact
Status Active, not recruiting
Phase Early Phase 1
Start date May 1, 2018
Completion date December 31, 2024

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