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Ciliary Motility Disorders clinical trials

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NCT ID: NCT03704896 Active, not recruiting - Clinical trials for Primary Ciliary Dyskinesia

PRospective Observational Multicentre Study on VAriability of Lung Function in Stable PCD Patients

PROVALF-PCD
Start date: August 23, 2017
Phase:
Study type: Observational

Using routinely collected clinical data, this study aims to quantify intra-individual (i.e. in the same individual) variations between measurements of lung function in stable patients with primary ciliary dyskinesia (PCD), a rare genetic disease that causes lung damage.

NCT ID: NCT03704207 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

Utility of PCD Diagnostics to Improve Clinical Care

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

This is a study evaluating the utility of current Primary Ciliary Dyskinesia (PCD) diagnostic tests, including nasal nitric oxide testing.

NCT ID: NCT03606200 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

Swiss Primary Ciliary Dyskinesia Registry

CH-PCD
Start date: January 2013
Phase:
Study type: Observational [Patient Registry]

The Swiss Primary Ciliary Dyskinesia (PCD) Registry is a national patient registry that collects information on diagnosis, symptoms, treatment and follow-up of patients with PCD in Switzerland and provides data for national and international monitoring and research.

NCT ID: NCT03517865 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

International Primary Ciliary Dyskinesia Cohort

iPCD
Start date: January 2013
Phase:
Study type: Observational

The iPCD Cohort is an international cohort that assembles available retrospective datasets and prospectively newly collected clinical and diagnostic data from patients suffering from primary ciliary dyskinesia (PCD) worldwide, to answer pertinent questions on clinical phenotype, disease severity, prognosis and effect of treatments in patients with this rare multiorgan disease.

NCT ID: NCT03494894 Completed - Cystic Fibrosis Clinical Trials

Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia

BAVASI
Start date: June 1, 2017
Phase:
Study type: Observational

Cytobacteriological examination of sputum and bacteriological sampling in the middle meatus.

NCT ID: NCT03370029 Completed - Clinical trials for Primary Ciliary Dyskinesia

Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia

Start date: October 2016
Phase:
Study type: Observational

Primary ciliary dyskinesia is an autosomal recessive disorder characterized by abnormal ciliary movement and disrupted mucociliary clearance. In uncleaned airways, microorganisms and respiratory irritants cause inflammation and infection. Permanent rhinitis and chronic sputum cough are typical features in primary ciliary dyskinesia patients. Primary ciliary dyskinesia is a disease that threatens lung function from pre-school age. One of the main causes of respiratory muscle weakness in chronic lung diseases diseases is worsening of lung function. Such a weakness causes alveolar hypoventilation, microatelectasis, reduction of the cough strength .The cough strength is important for airway cleaning. Exercise capacity is affected in chronic lung diseases. Assessment of exercise capacity in chronic lung diseases is prognostically important. Reduced exercise capacity and pulmonary function in PCD cause decrease in physical activity level. PCD patients have low quality of life and early recognition has been found to affect the quality of life positively. Children with chronic illness have higher level of depression than healthy children. In literature, no study investigated respiratory muscle strength, exercise capacity and physical activity PCD patients. Therefore, the investigators aimed to compare aforementioned outcomes in PCD patients and healthy controls.

NCT ID: NCT03320382 Recruiting - Asthma Clinical Trials

Multiple Breath Washout, a Clinimetric Dataset

Start date: May 5, 2017
Phase:
Study type: Observational

Monitoring patients with chronic, inflammatory airways disease particularly in the early stages is hampered by the relative insensitivity of current outcome measures to detect subtle changes. Multiple breath washout is a potential sensitive test that is a useful readout of disease at these early stages but it lacks standardisation and knowledge of variability with reference to standard lung function measures. This is a Cross sectional and longitudinal observation study. The hypothesis is that multiple breath washout-derived indices will provide a robust signal of gas mixing inhomogeneity, correlating with conventional measures of airway disease severity. Multiple breath washout performed on different devices will generate indices which correlate but differ in value.

NCT ID: NCT03279965 Recruiting - Cystic Fibrosis Clinical Trials

MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia

Start date: May 5, 2017
Phase: N/A
Study type: Observational

This is a small pilot / feasibility study (Approximately 50 patients) to assess the possibility of clinical implementation of MRI assessment of patients with cystic fibrosis and primary ciliary dyskinesia. Patients will undergo their standard CT imaging and lung function investigations and additionally will undergo MRI examination. Reports from CT (the current gold standard) and MRI will be assessed for concordance and patient acceptability and examination implementation costs will also be assessed. Novel MRI-based potential markers of CF and PCD disease state will also be assessed.

NCT ID: NCT03271840 Completed - Clinical trials for Primary Ciliary Dyskinesia

Registry for Primary Ciliary Dyskinesia

Start date: August 26, 2017
Phase:
Study type: Observational [Patient Registry]

Primary Ciliary Dyskinesia (PCD) is a rare disease, which means that any single PCD center has experience with a limited number of patients. PCD Registry is the collection of data about PCD from many centers and countries who treat children with PCD. Collecting data about PCD increase the knowledge on PCD, better describe the course of the disease, and help to better understand the progression of the disease and be used to develop new treatments. In the PCD registry of Alberta, important information about PCD such as time of diagnosis, symptoms, and tests which led to the diagnosis, state of health at diagnosis, the progression of lung function, the occurrence of severe infections, tests and treatments data will be collected from the patients' medical records.

NCT ID: NCT03256773 Recruiting - Covid19 Clinical Trials

High Resolution Micro OCT Imaging

Start date: April 15, 2016
Phase:
Study type: Observational

The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.