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Ciliary Motility Disorders clinical trials

View clinical trials related to Ciliary Motility Disorders.

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NCT ID: NCT04717115 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

Genotype/Phenotype Correlation With Focus on Lung Function in Primary Ciliary Dyskinesia (PCD)

LuFu_PCD
Start date: November 1, 2019
Phase:
Study type: Observational

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia associated with recurrent infections of the airways, laterality defects (Situs inversus totalis in about 50% of cases) and fertility problems. At present, mutations in > 45 genes associated with PCD and mucociliary clearance disorders have been identified, representing most likely two thirds of all human cases. Aim of this study are: - Correlation between genotype and lung function of patients with genetically confirmed PCD in an international cohort on a longitudinal basis - Determination of further parameters, such as body mass index (BMI), possibly associated with lung function in genetically confirmed PCD patients

NCT ID: NCT04702243 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults

Start date: December 1, 2020
Phase:
Study type: Observational

The investigators will utilize a systematic approach for the diagnostic evaluation of patients to identify characteristics which may distinguish between Primary Immunodeficiency (PID) disorders versus Primary Ciliary Dyskinesia (PCD).

NCT ID: NCT04611516 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD)

EPIC-PCD
Start date: March 2, 2020
Phase:
Study type: Observational

The Ear-Nose-Throat (ENT) Prospective International Cohort of patients with Primary Ciliary Dyskinesia (EPIC-PCD) is a prospective observational clinical cohort study, set up as a multinational multi-centre study. It is embedded into routine patient care of participating reference centres for PCD and patients keep being managed according to local procedures and guidelines.

NCT ID: NCT04602481 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

COVID-19 in People With Primary Ciliary Dyskinesia

Start date: May 31, 2020
Phase:
Study type: Observational

The COVID-PCD is a participatory research project that aims to study how COVID-19 affects people with primary ciliary dyskinesia (PCD). The study is advertised through patient support groups and participants register online and answer a baseline questionnaire with details on PCD diagnosis, habitual symptoms, and COVID-19 episodes occurring before study entry. A short weekly follow-up questionnaire includes questions on incident SARS-CoV-2 infections, current symptoms, social contact behaviour, and physical activity. Occasionally, participants receive extra questionnaires focused on special topics. The study is hosted at the University of Bern and recruitment started on May 30th, 2020.

NCT ID: NCT04489472 Recruiting - Clinical trials for Primary Ciliary Dyskinesia

The Effect of a Dietary Supplement Rich in Nitric Oxide in Patients Diagnosed With Primary Ciliary Dyskinesia.

Start date: July 31, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effect of a dietary supplement rich in nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on ciliary beat frequency assessed by high-speed digital video microscopy and on lung function assessed by spirometry in normal patients and patients with Primary ciliary dyskinesia (PCD).

NCT ID: NCT04476433 Completed - Asthma Clinical Trials

Intervention in Chronic Pediatric Patients and Their Families.

FACTORADAPT
Start date: February 4, 2019
Phase: N/A
Study type: Interventional

This project consists of a psychological intervention in patients and their families with different chronic diseases in order to carry out a comparative study between medical pathologies to know which are the protective or risk variables for the adaptation to the disease.

NCT ID: NCT04161313 Completed - Cystic Fibrosis Clinical Trials

Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children

Start date: December 20, 2019
Phase:
Study type: Observational

The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.

NCT ID: NCT03832491 Completed - Clinical trials for Primary Ciliary Dyskinesia

Effect of Game Based Approach on Oxygenation, Functional Capacity and Quality of Life in Primary Ciliary Dyskinesia

Start date: May 20, 2019
Phase: N/A
Study type: Interventional

Impaired pulmonary function, decreased physical activity, functional capacity and depending on these factors are reported in patients with primary ciliary dyskinesia in recent studies. The purpose of this study to evaluate the effects of game based approach on pulmonary function, functional capacity and quality of life in patients with primary ciliary dykinesia.

NCT ID: NCT03809091 Recruiting - Cystic Fibrosis Clinical Trials

WGS of Korean Idiopathic Bronchiectasis

WGS_UNK_BE
Start date: January 2019
Phase:
Study type: Observational [Patient Registry]

Whole genome sequencing of Korean patients with idiopathic bronchiectasis and their family will perform to identify disease-causing variants.

NCT ID: NCT03801395 Active, not recruiting - Clinical trials for Primary Ciliary Dyskinesia

PCD New Gene Discovery

Start date: January 7, 2019
Phase:
Study type: Observational

This is a new gene discovery program for individuals with PCD who do not have a specific genetic etiology identified. Research procedures involve a single blood draw from the affected individual and from unaffected family members in an effort to identify new genetic targets.