Chronic Periodontitis Clinical Trial
Official title:
Clinical Efficacy of Locally Delivered Aloe Vera Gel as an Adjunct to Non-surgical Periodontal Therapy in Chronic Periodontitis Subjects With Type 2 Diabetes Mellitus: a Randomized Controlled Clinical Trial
The present study is designed to investigate the effectiveness of AV gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of subjects with chronic periodontitis (CP) and type 2 diabetes mellitus (DM).
BACKGROUND: Advances in the field of alternative medicine have promoted widespread use of
herbal agents, like Aloe vera (AV), for both medical and dental therapy. AV has
anti-inflammatory, antioxidant, antimicrobial, hypoglycaemic, healing promoting and immune
boosting properties. The present study is designed to investigate the effectiveness of AV
gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of
subjects with chronic periodontitis (CP) and type 2 diabetes mellitus (DM).
MATERIAL AND METHODS: A total of 60 subjects with probing depth (PD) ≥5mm and clinical
attachment level (CAL) ≥3mm were randomly divided into two groups. Group 1 was treated with
SRP + placebo gel local drug delivery (LDD) and Group 2 with SRP + AV gel LDD. Clinical
parameters including full mouth plaque index (PI), modified sulcus bleeding index (mSBI),
probing depth (PD) and clinical attachment level (CAL) were recorded first at baseline and
then at intervals of 3 months and 6 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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