Chronic Periodontitis Clinical Trial
Official title:
Efficacy of Intensive Periodontal Therapy and Premedication With Oral Amoxicilline on Inflammatory Markers and Bacteremia in Patients With Chronic Periodontitis. A Randomized Controlled Trial.
There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment. The pre-surgical antibiotics have been studied particullary over Gram positive bacterial but not over gram negative bacterial and their secondary effects over the systemic pro-inflamation. Objective: to evaluate the efficacy of intensive periodontal therapy and pre-medication with oral amoxicilline on inflammatory bio-markers and the incidence, duration and magnitude of bacteremia in patients with chronic periodontitis.
A randomized, triple-blind clinical trial with 90 participants will be conducted (age
range18-65 years) with chronic periodontitis will be received and intensive periodontal
therapy under local anaesthesia. Participants will be randomly assigned using block
randomization in two groups. Test group premedication with 2 gr of oral amoxicilline 1 hour
before periodontal treatment and control group with 2 gr of placebo 1 hour before treatment.
High-sensitivity assays will be used to quantify serum concentrations of inflammatory marker
(Interleukin (IL-1β), Interleukin 6, Tumour necrosis factor α, MCP 1, C Reactive Protein
(CRP), plasma haemostatic (D-dimer), and von Willebrand factor antigen (r-WF:Ag).
Samples of blood will be taken at baseline (before treatment), inmediatly finished the
treatment, 30 minutes and 1, seven and 30 days after treatment to asses bacteremia and
inflammatory markers.
Bacterial isolation and identification: Bacterial colonies will be isolated on both selective
and nonselective culture medium for aerobes and anaerobes bacteria. Sensitive Digital
quantitative polymerase chain reaction will be used to quantify bacteria.
Concentrations of CPRus, inflammatory, haemostatic and endotellial cell activation markers
will be quantified by high-sensitive enzyme liked inmunosorbent assays according to the
manufacturer´s protocol. For each cytokine, comparisons between groups will be made by time.
The levels of cytokines expressed in picograms will be transformed into international units
for the statistical analysis.
In case it follows a normal distribution, an analysis of variance (ANOVA) for repeated
measurements between groups with post hoc corrections made by Wilcoxon test will be used. In
case it doesn´t follow a normal distribution, Non parametric test such as Friedman´s test
will be used. Values of p<0.05 will be accepted as statiscally significant.
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