Chronic Periodontitis Clinical Trial
— PAGOfficial title:
Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis
Verified date | February 2018 |
Source | Centre Hospitalier Universitaire de Nice |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Periodontitis are inflammatory diseases characterized by the destruction of the tooth-supporting bone due to increased bone resorption by osteoclasts (OCLs). Two forms are described: chronic periodontitis (CP) and aggressive periodontitis (AP) that differ by the severity and rapidity of bone loss, much more important for AP than CP. In both forms, the link with uncontrolled activation of the immune system is largely admitted. Despite the physiopathology of CP is fairly well studied, very few data are available regarding AP. The investigators aim is to understand the severity of AP by analyzing the proportion and action of immune and mesnchymal cells potentially involved in bone destruction, on biopsies of periodontal granulation tissue (surgical waste) and blood. Three groups of 20 patients will be included: affected with AP, CP or controls (necessitating an extraction of wisdom teeth).
Status | Terminated |
Enrollment | 8 |
Est. completion date | December 2017 |
Est. primary completion date | December 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
- Inclusion criterias for agressive periodontits - Young patients not suffering of any médical conditions - Small amount of calculus detected - Pocket depth >5mm - Alveolar Bone loss >50% - Inclusion criterias for chronic periodontitis - Evident presence of calculus above or under the gingiva - Pocket depth >5mm - Inclusion criterias for control patients : - Young patients in need of impacted wisdom teeth removal - And not suffering of chronic or agressive periodontitis - Exclusion criterias : - Patients with blood disorder - Patients presenting with liver, kidney, or vascular disorder, and /or psychiatric disorder - Patients who have allergies - Patients taking biphosphonates, anticoagulant drugs, or anticonvulsivant - Patients who have had a cancer of the mouth, and/or treated by radiotherapy - Patients who have taken anti-inflammatory drugs, and/or anti-cancer drugs, and/or immuno-suppresive drugs in the past 6 months - Patients who have had a periodontal treatment in the past 12 months - Pregnant Women - Patients juged difficult to follow by the investigator - Vulnerable patients |
Country | Name | City | State |
---|---|---|---|
France | Odontology Department, Nice Unversity Hospital | Nice |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Nice |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | proportion of lymphocytes, myeloid and mesenchymal populations in the samples | determined by flow cytometry | At the surgery time |
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