Chronic Periodontitis Clinical Trial
Official title:
Efficacy of Oral Probiotic and Antibiotic Administration in Clinical, Immunological and Microbiological Parameters of Patients With Chronic Periodontitis Treated With Non Surgical Periodontal Treatment
The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of
Lactobacillus rhamnosus SP1- containing probiotic tablets and azithromycin tablets as an
adjunct to scaling and root planning (SRP).
Material and methods: Fifty-four chronic periodontitis patients will be recruited and
monitored clinically, immunologically and microbiologically at baseline, 3, 6, 9 and 12
months after therapy. All patients will receive scaling and root planning and randomly will
be assigned over an probiotic experimental (SRP + probiotic, n=18), antibiotic experimental
(SRP + Azithromycin, n=18) or control (SRP + placebo, n=18) group. Probiotic will be used
once per day during 3 months. Antibiotic will be used once per day during 5 days.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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