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Clinical Trial Summary

The purpose of this study is to determine the recommended phase 2 dose of the drug Vorinostat in children, adolescents and young adults following allogeneic blood or marrow transplant (BMT) and determine whether the addition of Vorinostat to the standard graft versus host disease (GVHD) prophylaxis will reduce the incidence of GVHD.


Clinical Trial Description

All subjects will undergo allogeneic blood or marrow transplant (BMT) according to local site institutional practice. The preparative regimen will depend upon the subject's underlying disease, type of transplant, previous therapy and comorbidities. Stem cells can be from donors of bone marrow or peripheral blood stem cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03842696
Study type Interventional
Source University of Michigan Rogel Cancer Center
Contact
Status Recruiting
Phase Phase 1/Phase 2
Start date February 4, 2020
Completion date June 30, 2026

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