Chronic Heart Failure Clinical Trial
— MIBGinCRTOfficial title:
Single-photon Emission Computed Tomography for Prediction and Evaluation of Cardiac Resynchronization Therapy Efficacy in Chronic Heart Failure Patients
This study evaluates the state of the cardiac sympathetic activity and the severity of ventricular dyssynchrony in chronic heart failure patients and assesses the capabilities of radionuclide indication methods in determining the prognosis and evaluating the results of cardiac resynchronization therapy in chronic heart failure patients.
Status | Completed |
Enrollment | 60 |
Est. completion date | August 1, 2020 |
Est. primary completion date | August 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Chronic heart failure NYHA III and IV class - LVEF = 35 % - QRS = 150 ms on ECG - The presence of LBBB on ECG - Sinus rhythm - Optimal pharmacological treatment of heart failure Exclusion Criteria: - Contraindications to SPECT due to hypersensitivity to radiopharmacuticals such as 2-methoxy-isobutyl-isonitrile-(99mTc) and (123)I-Meta-iodobenzylguanidine or any of the excipients - Pregnancy - Breastfeeding - Refusal to participate |
Country | Name | City | State |
---|---|---|---|
Russian Federation | Cardiology Research Institute, Tomsk NRMC | Tomsk | Tomsk Region |
Lead Sponsor | Collaborator |
---|---|
Tomsk National Research Medical Center of the Russian Academy of Sciences |
Russian Federation,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | CRT response | ESV decreasing equal or more than 15% | One year |
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