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Chlamydia Trachomatis Infection clinical trials

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NCT ID: NCT04139629 Active, not recruiting - Infertility Clinical Trials

Cohort Study Investigating the Association Between Antichlamydial Antibody Positivity and ART Outcomes in Women With TFI

Start date: October 25, 2019
Phase: N/A
Study type: Interventional

In a prospective cohort study investigators will examine characteristics and clinical outcomes of treatment with ART in women with tubal factor infertility (TFI) with regard to seropositivity to antichlamydial antibodies.

NCT ID: NCT04050540 Active, not recruiting - HIV Infections Clinical Trials

Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP

dPEP-KE
Start date: February 5, 2020
Phase: Phase 4
Study type: Interventional

This is a randomized clinical trial of doxycycline post-exposure prophylaxis (dPEP) to reduce bacterial STIs among Kenyan women taking pre-exposure prophylaxis (PrEP). The overarching goal is to assess the effectiveness of dPEP on incidence of STIs while also balancing acceptability, cost, and impact on tetracycline resistance to inform public health policy. Participants will be randomized to receive dPEP and standard of care or the standard of care only. Questionnaires, focus group discussions, SMS, and in-depth interviews will be used to study acceptability and changes sexual behavior due to dPEP.

NCT ID: NCT03970850 Completed - Clinical trials for Chlamydia Trachomatis Infection

NeuMoDx PrEDiCTiNG Study Evaluation Plan

Start date: July 22, 2019
Phase: N/A
Study type: Interventional

This investigational study will be conducted to evaluate the performance of the NeuMoDx™ CT/NG Assay on the NeuMoDx™ 288 Molecular System and NeuMoDx™ 96 Molecular System (collectively referred to as NeuMoDx™ CT/NG Assay test system).

NCT ID: NCT03862495 Recruiting - Clinical trials for Chlamydia Trachomatis Infection

Genital CT Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Pilot RCT

RCT
Start date: May 21, 2020
Phase: N/A
Study type: Interventional

This study aims to identify the relationship between genital C. trachomatis and adverse pregnancy outcomes, and investigate whether screening and treatment of genital C. trachomatis in pregnant women can reduce adverse pregnancy outcomes. Approximately 200 pregnant women from Nanhai Hospital of Southern Medical University in Guangzhou, China will be enrolled and randomized to the intervention or control group.

NCT ID: NCT03568695 Completed - Clinical trials for Chlamydia Trachomatis Infection

Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples

ISTPOOL
Start date: June 29, 2018
Phase: N/A
Study type: Interventional

This study aims to compare the sensitivity of detecting Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium by real-time multiplex PCR in a pooled analysis (i.e. gathering pharyngeal, anorectal and urinary samples) versus the standard of care (where a real-time multiplex PCR is made in each of the three samples).

NCT ID: NCT03532464 Not yet recruiting - Vaginal Infection Clinical Trials

Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection

CHLAZIDOXY
Start date: July 1, 2018
Phase: Phase 4
Study type: Interventional

Chlamydia trachomatis is the most commonly reported bacterial sexually transmitted infection (STI), especially among young women. Up to 75% of C. trachomatis infected women are asymptomatic. If untreated, C. trachomatis infection can cause sequelae such as pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility. C. trachomatis can also cause anorectal infections, which are typically asymptomatic. Among women with urogenital chlamydial infection, around 36-91% also had concurrent anorectal chlamydial. Notably, there was no association with anal intercourse in the studies that reported it. However, guidelines do not recommend routine anorectal testing, but restricted testing in people who are in high-risk groups, report anal sexual behavior, or have anal symptoms, i.e., on selective indications. This is in contrast to urogenital testing, which is a routine procedure in STI care services. The anal transmission of C. trachomatis in women may occur by autoinoculation from the vagina due to the close proximity of the vagina and the anus. C. trachomatis could lead to a persistent infection in the lower gastrointestinal tract, suggesting the potential role of autoinoculation of cervical chlamydial infection from the rectal site. Such (repeat) urogenital infections could lead to reproductive tract morbidity. Recommended treatments for C. trachomatis infections are a single 1g dose of azithromycin or 100mg of doxycycline 2 times a day for 7 days. Although these two regimens are equivalent for urogenital infection, no study has compared the effectiveness of these two treatments on anorectal infection. If rectal C. trachomatis is a hidden reservoir influencing transmission rates, and considering the potential complications of cervical infections, providing further evidence of the need for effective rectal treatments among women is highly relevant.

NCT ID: NCT03107377 Completed - Clinical trials for Chlamydia Trachomatis Infection

Phase 2B/3 Double-blinded Placebo-controlled

Start date: November 3, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Phase 2B double-blind placebo-controlled efficacy trial of EVO100 (previously known as Amphora ® Gel) for the prevention of acquisition of urogenital Chlamydia trachomatis infection

NCT ID: NCT03098329 Completed - Gonorrhea Clinical Trials

Check it: A New Approach to Controlling Chlamydia Transmission in Young People

Start date: May 22, 2017
Phase: N/A
Study type: Interventional

This study, named "Check it," is a bundled program for African American (AA) men ages 15-24 that includes community testing for chlamydia and gonorrhea, expedited treatment for subjects who test positive and their female sexual contacts, and rescreening for these two sexually transmitted infections.

NCT ID: NCT02870101 Completed - Clinical trials for Sexually Transmitted Infections

Performance of Nucleic Acid Amplification Tests for the Detection of NG and CT

pNAAT
Start date: April 10, 2017
Phase: N/A
Study type: Interventional

The purpose of this study was to use participant samples to simultaneously evaluate three nucleic acid amplification tests (NAATs) diagnostic platforms.

NCT ID: NCT02694497 Completed - Clinical trials for Chlamydia Trachomatis Infection

Transmission of Genital and Extra-genital Chlamydia Trachomatis Infections in Women

FemCure
Start date: April 2016
Phase:
Study type: Observational

Multicenter prospective cohort study in Chlamydia trachomatis positive women after regular treatment to understand the transmission of anorectal CT infections.