Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage

Status Completed

Clinical Trial Summary

This study will evaluate acupuncture's effect of preventing vasospasm after SAH.

A total of 80 participants will be recruited and will be randomized to a study group or a control group. Acupuncture, electroacupuncture and intradermal acupuncture will be done at every session in a study group, while mock transcutaneous electrical nerve stimulation(mock TENS) and sham intradermal acupuncture will be carried out in a control group.

Clinical Trial Description

Intervention starts within 96hours after SAH, after ruptured aneurysms have been secured by endovascular coiling or surgical clipping. Intervention is applied once a day, 6 days a week for 2 weeks(total 12 sessions) in addition to standard treatment such as prophylactic HHH therapy and nimodipine. Sterile disposable, stainless steel acupuncture needles are used.

Primary outcome measurement is the occurrence of delayed ischemic neurological deficit between the study group and the control group. Moreover, the incidence of angiographic vasospasm, TCD vasospasm, and vasospasm-related infarct on CT or MRI, the change of nitric oxide(NO) and endothelin-1 in plasma, mortality and participant's functional status using mRS will be compared. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02275949
Study type	Interventional
Source	Kyung Hee University Hospital at Gangdong
Contact
Status	Completed
Phase	N/A
Start date	September 2014
Completion date	June 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02389634` - Identification of Novel Molecular Markers for Vasospasm
Completed	`NCT00962546` - Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage	N/A
Not yet recruiting	`NCT04512859` - Stellate Ganglion Block in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage	N/A
Completed	`NCT01024972` - Safety Study of Dantrolene in Subarachnoid Hemorrhage	Phase 1/Phase 2
Completed	`NCT00692744` - Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)	N/A
Completed	`NCT04208477` - "The Effect of Stellate Ganglion Block in Severe Brain Injury"	N/A
Recruiting	`NCT06303349` - Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers.	N/A
Recruiting	`NCT02129413` - Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm	N/A
Terminated	`NCT00487461` - Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage	N/A
Terminated	`NCT00582868` - Use of Brain Oxygen Tension Level and Cleaved-tau Protein to Detect Vasospasm After SAH	N/A
Withdrawn	`NCT01878136` - Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage	Phase 1/Phase 2
Withdrawn	`NCT01091870` - Sildenafil for Prevention of Cerebral Vasospasm	Phase 2
Completed	`NCT03214705` - Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage
Recruiting	`NCT05150002` - Cervical Spinal Cord Stimulation in Patients With Cerebral Vasospasm After Subarachnoid Haemorrhage: VasoStim Study	N/A
Completed	`NCT01187420` - Bilateral Bispectral Index (BIS) Study	N/A
Enrolling by invitation	`NCT05230134` - Cervical Sympathetic Block in Patients With Cerebral Vasospasm	N/A
Withdrawn	`NCT02426827` - Cervical Spinal Cord Stimulation in Cerebral Vasospasm	N/A
Withdrawn	`NCT00871065` - Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm	Phase 2
Recruiting	`NCT04691271` - Stellate Ganglion Block and Cerebral Vasospasm	N/A
Recruiting	`NCT02432157` - Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:	Phase 1/Phase 2