Subarachnoid Hemorrhage Clinical Trial
Official title:
Real Time Monitoring for Cerebral Vasospasm Using Bilateral Processed Electroencephalogram (EEG)
The purpose of this study is to assess real time changes in raw and processed EEG in relation to the clinical and radiological evidence of cerebral vasospasm.
Subarachnoid hemorrhage (SAH) is a prevalent and morbid condition (45%-30 day mortality).
One of the major causes of reduced cerebral blood flow (CBF) after initial SAH is cerebral
vasospasm. Early treatment of cerebral vasospasm (< 2 hr) is necessary for improved
neurologic outcome. Hence, there is significant interest in development of a monitor. The
most common bedside diagnostic tool is Transcranial Doppler (TCD) which is controversial
given its low sensitivity and specificity. TCD is not a continuous monitor and is user
dependent. Many centers rely on Cerebral Angiography for diagnosis of vasospasm; however
angiographic spasm does not correlate with outcome. EEG can detect changes in cerebral blood
flow which precede clinical decline but is technically difficult to perform and not
practical for continuous monitoring.
Processed EEG monitors have become somewhat popular in the operating setting for assessment
of depth of anesthesia. The recent introduction of bilateral 4 channel disposable probes
presents to opportunity to use EEG as a non-invasive continuous monitor for vasospasm. We
propose a prospective observational study to assess real time changes in raw and processed
EEG which we will correlate with clinical and radiologic evidence of vasospasm. Our primary
clinical endpoint will be the determination of delayed cerebral ischemia. This modality
could prove to be a significant clinical advantage for patients suffering from SAH.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT06043167 -
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
|
||
| Recruiting |
NCT04189471 -
Recovery After Cerebral Hemorrhage
|
||
| Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
| Completed |
NCT05131295 -
Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.
|
Phase 3 | |
| Recruiting |
NCT02962349 -
TRansfusion Strategies in Acute Brain INjured Patients
|
N/A | |
| Completed |
NCT02872857 -
Subarachnoid Hemorrhage Recovery And Galantamine
|
Phase 1/Phase 2 | |
| Terminated |
NCT02216513 -
Deferoxamine to Prevent Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
|
Phase 0 | |
| Completed |
NCT03164434 -
Influence of Drainage on EVD ICP-signal
|
||
| Completed |
NCT01077206 -
High-dose Simvastatin for Aneurysmal Subarachnoid Haemorrhage
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT00905931 -
Lycopene Following Aneurysmal Subarachnoid Haemorrhage
|
Phase 2 | |
| Completed |
NCT02389634 -
Identification of Novel Molecular Markers for Vasospasm
|
||
| Completed |
NCT00962546 -
Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage
|
N/A | |
| Completed |
NCT01261091 -
Early Tracheostomy in Ventilated Stroke Patients
|
N/A | |
| Completed |
NCT00507104 -
Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
|
||
| Completed |
NCT00071565 -
Familial Intracranial Aneurysm Study II
|
N/A | |
| Recruiting |
NCT05113381 -
The Purpose of This Study is to Determine Whether CerebroFlo™ EVD Catheter is Effective During the Treatment of IVH
|
N/A | |
| Completed |
NCT04052646 -
Prehospital Deaths From Spontaneous Subarachnoid Haemorrhages
|
||
| Recruiting |
NCT04548596 -
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
|
||
| Recruiting |
NCT06033378 -
Blood Pressure Treatment in ICU Patients With Subarachniodal Haemorrhage.
|
N/A | |
| Completed |
NCT04308577 -
Diet Induced Ketosis for Brain Injury - A Feasibility Study
|
N/A |