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Cataract clinical trials

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NCT ID: NCT01373853 Completed - Cataract Clinical Trials

A Single Centre Study to Compare the Efficacy and Safety of Femtosecond Laser-Assisted Versus Manual Cataract Surgery

1103
Start date: April 2011
Phase: Phase 3
Study type: Interventional

This clinical study is a controlled, open, prospective, single-centre, multi-surgeon eye study to determine the safety and efficacy of intraocular cuts for femtosecond laser assisted lens frag-mentation to support phacoemulsification of the cataractous lens prior to IOL implantation. The cuts are applied by means of the FEMTEC femtosecond laser system with the CustomLens soft-ware module using a cylindrical and radial cut pattern with diameter and height dependent on anterior chamber depth, pupil diameter and ocular lens size. The hypothesis of the study is that by means of femtosecond laser assisted lens fragmentation the required ultrasound energy used for phacoemulsification can be reduced in a safe and effective way.

NCT ID: NCT01367249 Completed - Pain Clinical Trials

Efficacy of Bromfenac Ophthalmic Solution in Patients Undergoing Cataract Surgery

Start date: May 2011
Phase: Phase 3
Study type: Interventional

This is an efficacy study of Bromfenac Ophthalmic Solution in cataract surgery.

NCT ID: NCT01351233 Completed - Cataract Clinical Trials

Evaluation of the Rotational Stability of The AcrySof Toric Intraocular Lens in the Capsular Bag in High Myopic Subjects

Start date: March 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the stability and efficacy of The AcrySof Toric intraocular lens in the bag in high myopic subjects.

NCT ID: NCT01344226 Completed - Inflammation Clinical Trials

Clinical Outcomes and Evaluation of Lotemax 0.5% in Treatment of Ocular Inflammation Associated With Cataract Surgery

Start date: April 2011
Phase:
Study type: Observational

Investigate the intraocular pressure(pressure inside the eye) of patients who are treated with Lotemax after undergoing cataract surgery.

NCT ID: NCT01334658 Completed - Cataract Clinical Trials

Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery

Start date: August 2010
Phase: N/A
Study type: Interventional

This is a study aimed at evaluating the effectiveness and impact of two intraocular irrigating solution (BSS ® versus glucose-bicarbonate-Ringer Lactate - GBRL) on the health of the cornea after cataract surgery by phacoemulsification.

NCT ID: NCT01330797 Completed - Cataract Clinical Trials

The Effect of Ranibizumab on Eye Lens Opacity in Cases With Age-Related Macular Degeneration

Start date: January 2009
Phase: N/A
Study type: Observational

Purpose To evaluate the cataractogenic effect of intravitreal ranibizumab with the use of Lens Opacity Classification System III (LOCS III). Settings Cases with a diagnosis of wet AMD were included in this university practice based prospective study. Methods All cases had monthly injections of intravitreal ranibizumab in the first 3 months; subsequently an OCT-guided pro re nata injection regimen has been adopted. All cases had a comprehensive eye examination and LOCS III evaluation at baseline and 1, 3, 6 and 12 months after the initial injection. Examination outcomes and change from baseline in LOCS III grades at 12 months were recorded. Results Eighteen eyes of 13 cases (7 female, 6 male) were included in this study. The mean age at the baseline was 75,3 + 6,6 years. A mean of 3,4 + 0,7 injections were given on each eye. Mean follow-up was 13,83 + 2,33 months. Baseline mean visual acuity improved from 1,04 + 0,10 logMAR units to 0,76 + 0,26 logMAR units after 3 injections (P < 0.05). At the 12th month of follow-up mean visual acuity was 0,71 + 0,27 logMAR units. According to LOCS III grades none of the cases had a prominent change in nuclear color, nuclear opalescence, cortical and posterior subcapsular opacification throughout the follow-up. IOP remained stable at all follow-up points. No complications were recorded throughout the study. Conclusion Intravitreal ranibizumab is an efficient treatment in wet AMD. Results of LOCS III assessments in this pilot study suggest that intravitreal ranibizumab has no effect on the progression of lens opacity.

NCT ID: NCT01323777 Completed - Cataracts Clinical Trials

AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL) Clinical Study in Japan

Start date: May 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate safety and effectiveness of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL Models SND1T3, SND1T4, SND1T5, and SND1T6 when implanted to replace the natural lens in Japanese cataract patients.

NCT ID: NCT01318499 Completed - Cataract Clinical Trials

Nepafenac 0.3% Two Study

Start date: March 2011
Phase: Phase 2
Study type: Interventional

The purpose of this study was to assess the safety and efficacy of Nepafenac Ophthalmic Suspension, 0.3% for the prevention and treatment of inflammation (swelling and redness) and pain in the eye after cataract extraction.

NCT ID: NCT01305616 Completed - Cataract Clinical Trials

Effect of Yellow-Tinted Intraocular Lens on Standard Automated Perimetry (SAP) and Short-wavelength Automated Perimetry (SWAP) in Patients With and Without Glaucoma

Start date: May 2008
Phase: N/A
Study type: Interventional

To investigate the effect of yellow-tinted IOLs on the Short Wave-length Automated Perimetry (SWAP) and Standard Automated Perimetry (SAP) in patients with and without glaucoma.

NCT ID: NCT01305005 Completed - Hypertension Clinical Trials

Effect of Phacoemulsification on Ocular Blood Flow in Human

Start date: March 2011
Phase:
Study type: Observational

- To investigate ocular haemodynamics after phacoemulsification surgery - To evaluate the influence in people with different autoregulation of ocular blood flow