Cardiovascular Patients With no Standard Modifiable Risk Factors

Cardiovascular Risk Factors Clinical Trial

— SMuRF-less-ME1  

Official title:

Absence of Standard Modifiable Risk Factors Among 5000 Middle Eastern Patients With Atherosclerotic Cardiovascular Disease: Clinical Profiles and Prevalence of Other Risk Factors and Comorbidities

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06199869
• Other study ID #: CVA2024.SMuRFless1
• Status: Recruiting
• Start date: January 22, 2024
• Est. completion date: January 31, 2025

Study information

• Verified date: January 2024
• Source: Jordan Collaborating Cardiology Group
• Contact: Ayman Hammoudeh, MD, FACC
• Phone: +96265001000
• Email: hammoudeh_ayman[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less). There is scarcity of studies that address this issue in the Middle Eastern population.

Description:

Atherosclerotic coronary artery disease (ASCAD) claims millions of lives annually on a global level and is the leading cause of death in the Middle East. There are four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, type 2 diabetes mellitus, dyslipidemia, and smoking. These are very common in the Middle East and are crucial to be screened for and addressed in an affective manner.

However, an increasing proportion of patients with ASCVD have none of these individual factors (SMuRF-less). Globally, this proportion comprises 11.6% of individuals with stable coronary disease and heart attack. No prior study has addressed the issue of the prevalence of SMuRF-less patients among the whole population of individuals with ASCVD in the Middle East.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 5000
• Est. completion date: January 31, 2025
• Est. primary completion date: January 1, 2025
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• A diagnosis of atherosclerotic cardiovascular disease (ASCVD).

• Ability to fill the clinical form that evaluates the presence or absence of cardiovascular risk factors including the 4 SMuRFs.

Exclusion Criteria:

• Atherosclerotic cardiovascular disease diagnosed before the age of 18 years.

• Inability to give detailed history of prespecified risk factors.

Related Conditions & MeSH terms

• Atherosclerosis
• Cardiovascular Diseases
• Cardiovascular Risk Factors

Intervention

Other:
• Evaluation of risk factors by direct interview with subjects who have atherosclerotic cardiovascular patients
Individuals identified with a diagnosis of ASCVD will fill a one page form of the associated risk factors they have

Locations

Country	Name	City	State
Jordan	Istishari Hospital	Amman
Jordan	Yarmouk University School of Medicine	Irbid

Sponsors (3)

Lead Sponsor	Collaborator
Jordan Collaborating Cardiology Group	The Jordan Cardiovascular Research Group JoCVRG, Yarmouk University School of Medicine

Country where clinical trial is conducted

Jordan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of patients who do not any of the four SMuRFs	Group of patients with definite ASCVD who do not have hypertension, diabetes, dyslipidemia or smoking.	Up to 4 weeks after study enrollment