Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05777564 |
| Other study ID # |
H-22064954 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
March 28, 2023 |
| Est. completion date |
February 8, 2024 |
Study information
| Verified date |
February 2024 |
| Source |
Frederiksberg University Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Background: Current knee osteoarthritis (OA) guidelines recommend knee specific exercise as
treatment for knee OA pain. However, up to 87 % of patients with knee OA have at least one
other chronic condition, typically cardiovascular in nature. The elevated risk of
cardiovascular health problems can be mitigated by performing aerobic exercise. By
consequence, it seems logical to apply aerobic exercise for this patient group as the
symptomatic benefit is equal to other types of exercise.
Aim: This study aims to assess the tolerability of cardiovascular exercise using High
Intensity Interval Training (HIIT) on different self-selected exercise equipment in patients
with knee OA and at least one CVD risk factor.
Hypothesis: The hypothesis is that performing HIIT exercise is tolerable when having knee OA
and at least one CVD risk factor.
Method:
The study is a prospective cohort study designed to assess if HIIT performed by patients with
knee OA and at least one modifiable CVD risk factor influence knee pain. The investigators
plan to include 40 participants. The participants will be recruited from the osteoarthritis
outpatient clinic at Bispebjerg-Frederiksberg hospital.
This study will include participants with a clinical diagnosis of knee OA (either one or both
knees) and at least one CVD risk factor (obesity, hypertension, elevated HbA1c (long-term
blood glycose), elevated triglycerides, elevated cholesterol (LDL)). All participants will
attend the HIIT intervention 3 times per week, for 12 weeks. Before a participant attend
their first exercise session, he/she will be asked to complete an educational session about
knee OA and aerobic exercise.
Participants will have a pre-screening visit (phone call), a screening visit, and a baseline
visit, before the 12-week exercise period (3 sessions weekly), and after completion of the
exercise period a follow-up visit.
Finance: This study is fully funded by Sygesikring "Denmark".
Publication: All results, both negative, positive, and inconclusive will be published. Should
publication fail, the results will be made publicly available.
Description:
BACKGROUND Current knee osteoarthritis (OA) treatment guidelines recommend knee specific
exercise as treatment for knee OA pain. If performed regularly, such knee-specific exercise
can yield a small to moderate effect on knee OA pain. However, muscle strengthening and
neuromuscular exercise are not the only types of exercise that can reduce knee pain; walking
regularly or aerobic exercise have similar positive effects on knee OA pain.
Up to 87 % of patients with knee OA have at least one other chronic condition. In the OA
population abdominal obesity and metabolic syndrome are more prevalent than in the general
population and knee OA is associated with increased risk for all-cause and cardiovascular
(CV) death.
It therefore seems logical to apply aerobic exercise for this patient group as the
symptomatic benefit is equal to other types of exercise.
AIM This study aims to assess the tolerability of cardiovascular exercise using High
Intensity Interval Training (HIIT) on different self-selected exercise equipment in patients
with knee OA and at least one CVD risk factor.
STUDY DESIGN The study is a prospective cohort study designed to assess if High Intensity
Interval Training (HIIT) performed by patients with knee OA and at least one modifiable CVD
risk factor influence knee pain.
The intervention will be performed with 3 sessions per week for 12 weeks. Due to the
feasibility-like nature of this study, we have not made formalized sample size calculations.
Approaches to the sample size justification for feasibility studies vary greatly. We plan to
include 40 participants, whom we believe are adequate to meet the aims of the study and
inform recruitment and sample size estimation for a subsequent large-scale randomized
controlled trial. The participants will be recruited from the osteoarthritis outpatient
clinic at Bispebjerg-Frederiksberg hospital. Participants that have completed the baseline
visit will not be replaced if they are prematurely terminated or withdraw study
participation.
DIAGNOSIS This study will include participants with a clinical diagnosis of knee OA (either
one or both knees) and at least one CVD risk factor (obesity, hypertension, elevated HbA1c
(long-term blood glycose), elevated triglycerides, elevated cholesterol (LDL)).
STUDY TREATMENT, HIIT All participants will attend the HIIT intervention 3 times per week,
for 12 weeks and one educational session. The educational session containing information on
rationale for aerobic exercise in knee OA and management of potential knee OA symptom flares.
The educational session will be led by health professionals with experience within the fields
of aerobic exercise and knee OA.
There will be several types of exercise equipment for aerobic exercise available (e.g.,
treadmill, cross-trainer, etc.) and participants will be asked to choose which they
preferrer. If, during the intervention period, participants change exercise equipment (either
due to pain or personal preference) this will be noted. There is no limit to the number of
modalities a participant may chose.
Resistance (speed, watt, and/or elevation) will be regulated continuously throughout the
intervention period to ensure the protocolized perceived exertion level are met at each
exercise session.
TREATMENT ADHERENCE Attendance to each session will be recorded as participants meeting at
the gym. Completion of the exercise sessions will be registered as perceived exertion (Borg)
during the intervals, total time on the exercise equipment, hearth rate monitoring, speed,
and resistance.
CONCOMITANT THERAPY All concomitant medications and treatments for knee OA should be kept
stable during study participation and will be recorded in the study database. During the
exercise period participants will be asked if the change their use of pain medication
(increase/decrease dose) and this will be registered.
PARTICIPANT SAFETY The study personnel and clinical staff will monitor each participant for
evidence of adverse event (AEs) throughout the study. The study personnel will assess and
record any AE in detail including the date of onset, description, severity, duration and
outcome, relation of the AE to study treatment, and any action(s) taken. In addition, a
work-EKG will be measured at the baseline-visit to ensure the HIIT-protocol is safe for the
participant (se Cardiopulmonary exercise test (VO¬2peak)).
Discontinuation of the entire study
The research group that initiated this study has the right to terminate this study at any
time. Reasons may include the following, but are not restricted to:
• The incidence of events in this or other studies that indicate a potential health hazard to
participants.
STUDY VISITS All consenting participants will undergo screening (assessment of eligibility),
fill out questionnaires, have a clinical examination, a blood sample drawn, and perform a
cardiovascular fitness test (VO¬2peak) before starting the exercise program. These initial
assessments will be repeated at the last study visit. All participants will attend the clinic
once for an educational session, and 3-weekly exercise sessions for 12 weeks.
Study completion The end-of-study is defined as the date of the last participant's last
scheduled visit or the actual date of follow-up contact, whichever is the longer.
DETERMINATION OF SAMPLESIZE AND STATISTICAL ANALYSIS PLAN Determination of sample size This
study is designed to assess tolerance of the purposed aerobic exercise intervention and
therefore, no sample size is performed. A convenience sample of 40 participant is considered
adequate to assess the tolerance of the study intervention and inform recruitment and sample
size estimation for a subsequent large-scale randomized controlled trial.
Statistical consideration The statistical analyses will be described in detail in a
statistical analysis plan to be completed before the last participant's last visit. For
assessment of the aim (tolerance) all participants included in the study (completion of
baseline visit) will be counted in the summation of results (intention-to-treat principle).
If relevant, scores will be presented as mean/median with lower and upper limits. Occurrence
of AEs will be reported in detail. The statistical tests of change for KOOS, VO¬2peak, blood
sample outcomes, weight, and blood pressure will be two-sided and statistical significance
will be claimed if the computed p-value is equal to or lower than 0.05.
RESEARCH ETHICS All participants are informed of their rights to withdraw from the study at
any time without this impacting on any future investigations and/or treatments at any site or
by some of the members of the study group.
After information is delivered, read, and understood, voluntary informed consent is given by
the participants by signing a consent form before study participation can take placePrior to
consent, it must be ensured that a potential participant have been given sufficient time to
consider his or her participation.
Aerobic exercise at high intensities can cause discomfort due to breathlessness, which is why
trained health professional are present at each exercise session to help guide participants
through the sessions and observe if any unexpected reactions occur. Breathlessness is
necessary for the exercise intervention to have an effect on the cardiopulmonary system.
Symptomatic flares (knee pain) are not unlikely to occur during the first period of the
exercise program, but these are expected to subside as the participant and his/her knee get
accustomed to the exercise program. The participants will be fully informed about this aspect
of the intervention. If participants are uncomfortable or experience unexpected reactions to
the exercises the health professional present will react professionally and provide best care
for the participant and refer to medical examination if judged necessary.
Health research ethical approval This protocol, the informed consent form, written patient
information, any anticipate advertising materials, and relevant supporting information will
be submitted to the health research ethical committee system by the study coordinator
(Cecilie Bartholdy) prior to study initiation. The study will be conducted in accordance with
the Danish law, the Helsinki declaration, and health research ethics committee requirements.
The study coordinator is responsible for keeping the committee informed of amendments or
changes to the protocol, and the progress of the study, as appropriate.
SOURCE DOCUMENTS AND DATABASES This research study group/institution will permit
study-related monitoring, audits, and regulatory inspection(s) access to source data
documents.
Study database This study will use an in-house custom-built electronic study database and an
in-house custom-built electronic data capture system (Cirkeline). The applications meet all
regulatory standards and allow management of all activities related to a clinical study,
ensuring optimal resource use and safety according to good clinical practice and data
protection legislation.
REGULATORY STANDARDS Participant confidentiality Participants medical information obtained by
this study is confidential, and disclosure to third parties other than those noted below is
prohibited.
If data from this study are published, the presentation format will not include names,
recognizable photos, personal information, or other data which compromises the anonymity of
participating participants.
Data Protection Act and General Data Protection Regulation The study will be conducted in
accordance with the Data Protection Act and follow the General Data Protection Regulation.
The study data management and data security procedures will be approved by the Regional
Knowledge Center on Data Protection Compliance (videnscenter for dataanmeldelser i Region
Hovedstaden).
Quality assurance All data will be entered into a study database for analysis and reporting.
Any data captured electronically will be stored electronically in a separate database
according to standard procedures at the Parker Institute. Upon completion of data entry, the
database will be checked to ensure acceptable accuracy and completeness. System backups and
record retention for the study data will be consistent with the Parker Institute standard
procedures.
Financing and insurance information The study is initiated by Professor Marius Henriksen and
post doc Cecilie Bartholdy who have received full funding from Sygeforsikringen "danmark" for
the specific purpose to complete this study and a subsequent randomized controlled trial
(total 5.6 mio DKK). None from the research group have conflicts of interests related to the
funding of this study. This information is disclosed to all participants in the written
information material.
All sources of support (including technical and financial) provided for this study is
disclosed in the written information material and in publication of the study results. All
future financial and/or technical support to the study is disclosed to alle participants
(previous, current, and potential) in the written information material.
The participants are insured by the Danish Patient Insurance Association. Financing and
insurance issues are addressed in the written information material.
PUBLICATION Development of the core publication will be coordinated by the research group,
that consist of people who have provided significant input into study design, implementation,
conduct, and interpretation as recommended by the international committee of medical journal
editors (ICMJE).
I accordance with the principles of the Helsinki Declaration, all results in this study,
positive as well as negative, and inconclusive will be published. If publication, for any
given reason fails, the results will be made publicly available.
